93958-38-4Relevant articles and documents
Studies in Potential Filaricides: Part XVI - Synthesis of 2,4-Disubstituted Aminophenols and Related Benzophenones as Amodiaquine Analogs
Agrawal, V. K.,Sharma, Satyavan
, p. 839 - 843 (2007/10/02)
A series of 2,4-disubstituted aminophenols (6-16, 18, 19, 22, 25) and substituted benzophenones (17, 20, 21, 23, 24, 33-35) and benzimidazoles (26-31) have been prepared starting from 2-substituted 4-aminophenols (1-3) or 4-chloro-4'-hydroxy-3-nitrobenzophenone (5).The mechanism of formation of benzimidazol-2-one by the reaction of o-phenylenediamine with 1,3-dicarbethoxy-S-methylisothiourea in refluxing DMF is also discussed.A number of compounds have been tested for their antifilarial, antihookworm and cestodicidal activities against Litomosoides carnii, Ancylostoma ceylanicum and Hymenolepis nana respectively in rodents but none of them shows any significant activity.