93968-73-1Relevant articles and documents
A combined experimental and theoretical investigation on the role of halide ligands on the catecholase-like activity of mononuclear nickel(II) complexes with a phenol-based tridentate ligand
Adhikary, Jaydeep,Chakraborty, Prateeti,Das, Sudhanshu,Chattopadhyay, Tanmay,Bauza, Antonio,Chattopadhyay, Shyamal Kumar,Ghosh, Bipinbihari,Mautner, Franz A.,Frontera, Antonio,Das, Debasis
, p. 13442 - 13452 (2013)
Three new mononuclear nickel(II) complexes, namely, [NiL1(H 2O)3]I2·H2O (1), [NiL 1(H2O)3]Br2·H2O (2), and [NiL1(H2O)3
Synthesis, structure, DNA/protein binding, molecular docking and in vitro anticancer activity of two Schiff base coordinated copper(II) complexes
Manna, Subal Chandra,Mistri, Soumen,Patra, Apu,Mahish, Manas Kumar,Saren, Dama,Manne, Rajesh Kumar,Santra, Manas Kumar,Zangrando,Puschmann
, p. 77 - 85 (2019)
Two Schiff bases HL and HL′, having potential tridentate O,N,N′ donor sets, have been used for the synthesis of two copper(II) complexes, namely [Cu(HL)(pdc)]2 (1) and [Cu(L′)2]2 (2′), where HL = 2-([2-(piperazin-yl)ethyli
Syntheses and characterization of monobasic tridentate Cu(II) Schiff-base complexes for efficient oxidation of 3,5-di-: tert -butylcatechol and oxidative bromination of organic substrates
Kumari, Sweta,Mahato, Arun Kumar,Maurya, Abhishek,Singh, Vijay Kumar,Kesharwani, Neha,Kachhap, Payal,Koshevoy, Igor O.,Haldar, Chanchal
, p. 13625 - 13646 (2017/11/27)
Two monomeric copper complexes [CuII(sal-ppzH)Cl2] (1) and [CuII(hyap-ppzH)Cl2] (2) were synthesized by reacting CuCl2·2H2O with the monobasic tridentate Schiff-base ligands [Hsal-ppz] (I) and [Hyap-ppz] (II) (derived by reacting 1-(2-aminoethyl) piperazine with salicylaldehyde and 2-hydroxyacetophenone) respectively. Elemental analysis, IR, UV-Vis, 1H NMR and 13C NMR data confirm the structures of the ligands and those of the complexes. Both complexes are monomeric in nature in the solid state and in solution as well. Single crystal XRD data suggest a distorted square pyramidal geometry for 1 crystallized in the P1 space group. DFT studies established a similar molecular structure for 2. The synthesized metal complexes [CuII(sal-ppzH)Cl2] (1) and [CuII(hyap-ppzH)Cl2] (2) successfully catalyzed the oxidation of 3,5-di-tert-butylcatechol (3,5-DTBC) in methanol in the presence of H2O2 with high Kcat values of 1.182 × 104 mmol h-1 and 2.880 × 104 mmol h-1, respectively. [CuII(sal-ppzH)Cl2] (1) and [CuII(hyap-ppzH)Cl2] (2) were also anchored into the polymeric matrix of chloromethylated polystyrene and were analyzed by TGA, atomic absorption spectroscopy (AAS), EPR, scanning electron microscopy (SEM) as well as energy dispersive X-ray (EDX) analysis. The polymer grafted metal complexes were used as catalyst precursors in the oxidative bromination of salicylaldehyde in the presence of H2O2, KBr and HClO4. Under optimized reaction conditions, both catalysts show nearly quantitative oxidative bromination of salicylaldehyde, with the order of % products formed being 5-bromosalicylaldehyde > 3,5-dibromosalicylaldehyde > 3-bromosalicylaldehyde. Plausible reactive species involved in the catalytic cycle are identified by UV-Vis spectroscopy, pH metric titration, ESI-MS, EPR and DFT studies.
Configuration change from cis to trans of isothiocyanato groups in nickel(II) species: Experimental verification and theoretical interpretation of reaction consequence and study on their bio-activity
Adhikary, Jaydeep,Chakraborty, Prateeti,Chattopadhyay, Tanmay,Prasad, Ritika,Motro, Yair,Koch, Biplob,Mautner, Franz A.,Miller, Yifat,Das, Debasis
, p. 55 - 65 (2015/04/27)
Two new mononuclear Ni(II) complexes, namely [Ni(HL)(SCN)2(H2O)] (1) and [Ni(HL)(SCN)2(4,4′-bipy)] (2) [HL = 2-[(2-piperazin-1-yl-ethylimono)-methyl]phenol] have been synthesized and structurally characterized. The uncoordinated nitrogen atom of the piperazine moiety is protonated to provide electrical neutrality to the system. The configuration of the isothiocyanato ligands is different in the two complexes, cis located in 1 and trans in complex 2. The change of configuration of the isothiocyanato groups on addition of the neutral spacer 4,4-bipyridine to complex 1 has been monitored by conductometric and FTIR spectral studies and the most probable mechanistic pathway has been proposed. DFT calculations have been performed and the outcome corroborates well with the experimental facts. The anticancer activity of the two Ni(II) complexes has been evaluated in human cervical (HeLa) cancer and breast cancer (MCF-7) cell lines. The cytotoxic effects of these complexes were determined by an MTT assay. The fluorescent intensity obtained in HeLa cells reveals the generation of ROS by the complexes using DCFH-DA (2,7-dichlorofluorescein diacetate) dye. The apoptotic cell death was determined by fluorescent staining with acridine orange and ethidium bromide, which confirmed the presence of apoptotic cells. Further, flow cytometry analysis was done, suggesting an arrest of the cell cycle in the S phase of the HeLa cells. Although a detailed molecular mechanism for the anticancer activity of the two complexes was not ascertained, the experimental results suggest that both complexes are effective anticancer agents, with complex 2 seeming to be more promising. The result also indicates that the apoptotic cell death in the cancer cell might be triggered by the process of ROS generation with the complexes. Thermo gravimetric analysis of two complexes hints that NiO particles are the final product after decomposition of the complexes at 600 °C.
