939758-75-5

Basic information

• Product Name: 7-Fluoro-1,2,3,4-tetrahydroquinoline
• Synonyms: 7-Fluoro-1,2,3,4-tetrahydroquinoline
• CAS NO: 939758-75-5
• Molecular Formula: C9H10FN
• Molecular Weight: 151.1808032
• Mol File: 939758-75-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 232.8°C at 760 mmHg
• Flash Point: 94.6°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 0.0578mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: 7-Fluoro-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Fluoro-1,2,3,4-tetrahydroquinoline(939758-75-5)
• EPA Substance Registry System: 7-Fluoro-1,2,3,4-tetrahydroquinoline(939758-75-5)

Safety Data

• Hazardous Substances Data: 939758-75-5(Hazardous Substances Data)

Usage

General Description

7-Fluoro-1,2,3,4-tetrahydroquinoline is a chemical compound with the molecular formula C9H10FN. It is a fluorinated derivative of tetrahydroquinoline, which is a heterocyclic compound commonly found in various natural products and pharmaceutical drugs. 7-Fluoro-1,2,3,4-tetrahydroquinoline has potential applications in medicinal chemistry and drug development due to its structural features and biological activities. Its fluorinated moiety can enhance the compound's pharmacokinetic properties and increase its binding affinity to target proteins, making it a valuable scaffold for the design of new drug candidates. Additionally, the presence of the fluorine atom can also introduce unique chemical reactivity and selectivity, expanding the compound's synthetic and pharmaceutical potential. Overall, 7-Fluoro-1,2,3,4-tetrahydroquinoline is a promising chemical entity with important implications for drug discovery and development.

InChI:InChI=1/C9H10FN/c10-8-4-3-7-2-1-5-11-9(7)6-8/h3-4,6,11H,1-2,5H2

Upstream product

• 364-78-3 2-nitro-4-fluoroaniline 
• 313545-72-1 2-chloro-4-fluorophenylboronic acid 
• 396-32-7 7-Fluoroquinoline 
• 100638-26-4 3-chloro-N-(3-fluoro-phenyl)-propionamide 
• 372-19-0 meta-fluoroaniline 
• 114417-35-5 7-fluoro-2,3-dihydro-1H-quinolin-4-one 
• 4590-52-7 7-fluoro-3,4-dihydro-1H-quinolin-2-one 

Relevant articles and documents

Dehydrogenative and Redox-Neutral N-Heterocyclization of Aminoalcohols Catalyzed by Manganese Pincer Complexes

A new manganese catalyzed heterocyclization of aminoalcohols has been accomplished. A wide range of heterocycles were synthesized, including 1,2,3,4-tetrahydroquinolines, dihydroquinolinones, and 2,3,4,5-tetrahydro-1H-benzo[b]azepines. The reaction is performed under mild reaction conditions using air and moisture stable manganese catalysts. The desired heterocycles were obtained in good to excellent yields.

Discovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists

The retinoic acid receptor-related orphan receptor γt (RORγt) is an important nuclear receptor that regulates the differentiation of Th17 cells and production of interleukin 17(IL-17). RORγt agonists increase basal activity of RORγt and could provide a potential approach to cancer immunotherapy. Herein, hit compound 1 was identified as a weak RORγt agonist during in-house library screening. Changes in LHS core of 1 led to the identification of tetrahydroquinoline compound 6 as a partial RORγt agonist (max. act. = 39.3%). Detailed structure-activity relationship on substituent of the LHS core, amide linker and RHS arylsulfonyl moiety was explored and a novel series of tetrahydroquinolines and benzomorpholines was discovered as potent RORγt agonists. Tetrahydroquinoline compound 8g (EC50 = 8.9 ± 0.4 nM, max. act. = 104.5%) and benzomorpholine compound 9g (EC50 = 7.5 ± 0.6 nM, max. act. = 105.8%) were representative compounds with high RORγt agonistic activity in dual FRET assay, and they showed good activity in cell-based Gal4 reporter gene assay and Th17 cell differentiation assay (104.5% activation at 300 nM of 8g; 59.4% activation at 300 nM of 9g). The binding modes of 8g and 9g as well as the two RORγt inverse agonists accidentally discovered were also discussed.

4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.