939792-77-5Relevant articles and documents
Nickel-Catalyzed Amination of α-Aryl Methyl Ethers
Patel, Purvish,Rousseaux, Sophie A. L.
, p. 492 - 496 (2020/03/13)
α-Aryl amines are prevalent in pharmaceutically active compounds and natural products. Herein, we describe a Ni-catalyzed protocol for their synthesis from readily available α-aryl ethers. While α-aryl ethers have been used as electrophiles in Ni-catalyzed C-C bond formations, their use in C-heteroatom bond formation is much less prevalent. Preliminary mechanistic insight suggests that oxidative addition is facilitated by an anionic ligand and that reductive elimination is a reversible process.
A new copper(I)-catalyzed cycloetherification/acid-catalyzed allylic nucleophilic substitution for one-pot synthesis of 2-substituted benzofurans
Li, Xin,Xue, Jijun,Chen, Rui,Li, Ying
, p. 1043 - 1046 (2012/06/04)
A new copper(I)-catalyzed cycloetherification followed by an acid-catalyzed allylic nucleophilic substitution have been developed for the one-pot synthesis of 2-substituted benzofurans. This one-pot reaction proceeds efficiently under extremely mild conditions with simple and inexpensive catalysts, providing diversely substituted benzofurans in good to excellent yields. Georg Thieme Verlag Stuttgart. New York.
A facile approach to the synthesis of chiral 2-substituted benzofurans
De Luca, Lidia,Giacomelli, Giampaolo,Nieddu, Giammario
, p. 3955 - 3957 (2008/02/01)
(Chemical Equation Presented) An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of α-alkyl-2- benzofuranmethanamines from N-protected α-amino ac
