93982-04-8Relevant articles and documents
Synthesis of [2H4]oxymetazoline and [ 14C]oxymetazoline
Brugger, Michelle L.,Borges, Scott,Ren, Sumei,McNamara, Paul
experimental part, p. 793 - 795 (2012/03/08)
An efficient synthesis of [2H4] and [ 14C]oxymetazoline has been developed. Both compounds follow the same synthetic route with the introduction of the label occurring at different synthetic steps. The synthesis of [2H4]oxymetazoline from [2H4]ethylene diamine was achieved in one step with a 40% yield. The synthesis of [14C]oxymetazoline from potassium [ 14C]cyanide was achieved in two steps with an overall radiochemical yield of 67%. Copyright