939822-86-3

Basic information

• Product Name: 6-cyanonaphthalen-2-yl 4-methylbenzenesulfonate
• Synonyms: 6-cyanonaphthalen-2-yl 4-methylbenzenesulfonate
• CAS NO: 939822-86-3
• Molecular Weight: 323.372
• Mol File: 939822-86-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 6-cyanonaphthalen-2-yl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 6-cyanonaphthalen-2-yl 4-methylbenzenesulfonate(939822-86-3)
• EPA Substance Registry System: 6-cyanonaphthalen-2-yl 4-methylbenzenesulfonate(939822-86-3)

Safety Data

• Hazardous Substances Data: 939822-86-3(Hazardous Substances Data)

Upstream product

• 86164-70-7 2-methyl-2-phenylmalononitrile 
• 411219-20-0 6-bromonaphthalen-2-yl 4-methylbenzenesulfonate 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 52927-22-7 6-cyano-2-naphthol 

Downstream Products

• 52927-22-7 6-cyano-2-naphthol 
• 1231261-89-4 6-(4-methoxypheny)naphthalene-2-carbonitrile 

Relevant articles and documents

Ni-Catalyzed Reductive Cyanation of Aryl Halides and Phenol Derivatives via Transnitrilation

Herein, we report a Ni-catalyzed reductive coupling for the synthesis of benzonitriles from aryl (pseudo)halides and an electrophilic cyanating reagent, 2-methyl-2-phenyl malononitrile (MPMN). MPMN is a bench-stable, carbon-bound electrophilic CN reagent that does not release cyanide under the reaction conditions. A variety of medicinally relevant benzonitriles can be made in good yields. Addition of NaBr to the reaction mixture allows for the use of more challenging aryl electrophiles such as aryl chlorides, tosylates, and triflates. Mechanistic investigations suggest that NaBr plays a role in facilitating oxidative addition with these substrates.

Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors

The two isoforms of sphingosine kinase (SphK1 and SphK2) are the only enzymes that phosphorylate sphingosine to sphingosine-1-phosphate (S1P), which is a pleiotropic lipid mediator involved in a broad range of cellular processes including migration, proliferation, and inflammation. SphKs are targets for various diseases such as cancer, fibrosis, and Alzheimer's and sickle cell disease. Herein, we disclose the structure-activity profile of naphthalene-containing SphK inhibitors and molecular modeling studies that reveal a key molecular switch that controls SphK selectivity.

INTERMEDIATES AND PROCESS FOR THE PREPARATION OF AROMATIC DERIVATIVES OF 1-ADAMANTANE

Process for the preparation of aromatic derivatives of 1 -adamantane (tricyclo[3.3.1.1 (3,7)]decane), or an acceptable pharmaceutical salt thereof, based on a hydrolysis reaction of a precursor cyano compound. It also comprises different processes for obtaining the cyano compound. It is especially useful for obtaining Adapalene on an industrial scale in high yield and purity. It also comprises new intermediates useful in said preparation process.