94-18-8 Usage
Description
Benzylparaben, also known as Benzyl 4-hydroxybenzoate or Paraben, is an ester of para-hydroxy benzoic acid. It is a white to light yellow fine powder that has been added to various cosmetics and personal care products as a preservative. Its quantification in cosmetics has been reported by HPLC methods. Benzylparaben is an endocrine disrupting chemical (EDC) and is a promising candidate for use in pharmaceutical and personal care products.
Uses
Used in Cosmetics and Personal Care Products:
Benzylparaben is used as a preservative in cosmetics and personal care products to prevent the growth of microorganisms and extend the shelf life of the products.
Used in Pharmaceutical Preparations:
Benzylparaben is used as a preservative in pharmaceutical preparations to maintain the stability and safety of the products.
Used in Analytical Chemistry:
Benzylparaben may be used as an internal standard for the simultaneous analysis of non-steroidal anti-inflammatory drugs in human plasma and urine using microextraction by packed sorbent and HPLC method. It may also be employed as an internal standard for the HPLC determination of rutin, kaempferol, genistein, formononetin, and biochanin A in Ononis spinosu roots.
General Description:
Benzylparaben is an ester of para-hydroxy benzoic acid that has been added to various cosmetics and personal care products as a preservative. Its quantification in cosmetics has been reported by HPLC methods. Microwave-assisted synthesis of benzylparaben by reaction between (4-hydroxybenzoic) acid and K2CO3 in the presence of a phase transfer catalyst has been reported. It is an endocrine disrupting chemical (EDC) and is a promising candidate for use in pharmaceutical and personal care products. Its visible-light assisted photosensitized degradation in a homogeneous aqueous solution of 4,4′,4′′,4′′′-(porphine-5,10,15,20-tetrayl)tetrakis(benzenesulphonic acid) has been investigated.
Flammability and Explosibility
Notclassified
Contact allergens
This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid
and an alcohol. They are largely used as biocides in
cosmetics and toiletries, medicaments, or food. They
have synergistic power with other biocides. Parabens
can induce allergic contact dermatitis, mainly in
chronic dermatitis and wounded skin.
Check Digit Verification of cas no
The CAS Registry Mumber 94-18-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 4 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 94-18:
(4*9)+(3*4)+(2*1)+(1*8)=58
58 % 10 = 8
So 94-18-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H12O3/c15-13-8-6-12(7-9-13)14(16)17-10-11-4-2-1-3-5-11/h1-9,15H,10H2
94-18-8Relevant articles and documents
Esterification of sodium 4-hydroxybenzoate by ultrasound-assisted solid-liquid phase-transfer catalysis using dual-site phase-transfer catalyst
Yang, Hung-Ming,Chu, Wei-Ming
, p. 395 - 400 (2014)
The catalytic esterification of sodium 4-hydroxybenzoate with benzyl bromide by ultrasound-assisted solid-liquid phase-transfer catalysis (U-SLPTC) was investigated using the novel dual-site phase-transfer catalyst 4,4′-bis(tributylammoniomethyl)-1,1′-bip
A simple and effective synthesis of 3- And 4-((Phenylcarbamoyl)oxy)benzoic acids
Gobec, Stanislav,Ko?ak, Urban
, p. 940 - 948 (2020/10/02)
Phenserine, posiphen, tolserine and cymserine and its derivatives are experimental Alzheimer's disease drugs that contain a phenyl phenylcarbamate moiety that is responsible for their anti-Alzheimer activities. We have developed a simple (3 steps) and effective (overall yields 76-90%) method for preparing 3- and 4-((phenylcarbamoyl)oxy)benzoic acids which can be reacted with amines to produce phenyl phenylcarbamate moiety containing amides as new potential anti-Alzheimer disease drugs. The synthesized carboxylic acids are thus important building blocks with potential use in medicinal chemistry and drug discovery.
A process for the preparation of hydroxy-benzoic acid benzyl ester
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Paragraph 0034; 0035, (2017/03/17)
The invention discloses a preparation method for benzyl 4-hydroxybenzoate. The preparation method comprises: taking 4-hydroxybenzoic acid and benzyl alcohol as main raw materials, dibutyltin oxide or tetraisopropoxy titanium as a catalyst and xylene as a water-carrying agent, at the nitrogen atmosphere, heating, and performing reflux condensation and water diversion to promote the reaction. The preparation method aims at improving synthetic efficiency of benzyl 4-hydroxybenzoate and product yield. According to the preparation method for benzyl 4-hydroxybenzoate, due to the facts that dibutyltin oxide or tetraisopropoxy titanium is taken as a catalyst, xylene is taken as a water-carrying agent, benzyl 4-hydroxybenzoate is synthesized by heating 4-hydroxybenzoic acid and benzyl alcohol at the nitrogen atmosphere, the preparation method helps to effectively improve synthetic efficiency, reduce generation of by-products, improve product yield, reduce production cost of the product, reduce separation difficulty and improve product purity and quality.
