940763-48-4

Basic information

• Product Name: 1-benzyl-7-bromoindoline-2,3-dione
• Synonyms: 1-benzyl-7-bromoindoline-2,3-dione
• CAS NO: 940763-48-4
• Molecular Weight: 316.154
• Mol File: 940763-48-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 1-benzyl-7-bromoindoline-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-7-bromoindoline-2,3-dione(940763-48-4)
• EPA Substance Registry System: 1-benzyl-7-bromoindoline-2,3-dione(940763-48-4)

Safety Data

• Hazardous Substances Data: 940763-48-4(Hazardous Substances Data)

Upstream product

• 20780-74-9 7-bromoisatin 
• 620-05-3 iodomethylbenzene 
• 100-39-0 benzyl bromide 

Downstream Products

• 1263090-28-3 C₂₈H₂₀BrNO₄ 
• 1391858-24-4 (2'S,3'R,4'S)-5',5'-diethyl 3',4'-dimethyl 1-benzyl-7-bromo-2-oxospiro[indoline-3,2'-pyrrolidine]-3',4',5',5'-tetracarboxylate 
• 1391858-37-9 (2'S,3'R)-5',5'-diethyl 3'-methyl 1-benzyl-7-bromo-2-oxospiro[indoline-3,2'-pyrrolidine]-3',5',5'-tricarboxylate 
• 1391860-27-7 (2'S,3'R,4'R)-5',5'-diethyl 3',4'-dimethyl 1-benzyl-7-bromo-2-oxospiro[indoline-3,2'-pyrrolidine]-3',4',5',5'-tetracarboxylate 
• 1391858-47-1 (2'R,3'S)-trimethyl 1-benzyl-7-bromo-2-oxo-3'-phenylspiro[indoline-3,2'-pyrrolidine]-3',5',5'-tricarboxylate 
• 1391858-31-3 (2'S,3'R,4'S)-tetramethyl 1-benzyl-7-bromo-2-oxospiro[indoline-3,2'-pyrrolidine]-3',4',5',5'-tetracarboxylate 
• 1391858-41-5 (2'S,3'R)-trimethyl 1-benzyl-7-bromo-2-oxospiro[indoline-3,2'-pyrrolidine]-3',5',5'-tricarboxylate 
• 1402818-24-9 C₁₈H₁₀BrN₃O 
• 1376615-75-6 C₂₉H₃₃BrN₂O₄ 
• 1366339-67-4 (R)-3-amino-1-benzyl-7-bromo-3-methylindolin-2-one 
• 1366043-14-2 (R)-1-benzyl-7-bromo-3-hydroxy-3-((S)-2-nitro-1-phenylethyl)indolin-2-one 

Relevant articles and documents

Organocatalytic Asymmetric Synthesis of Aza-Spirooxindoles via Michael/Friedel-Crafts Cascade Reaction of 1,3-Nitroenynes and 3-Pyrrolyloxindoles

An asymmetric [3+3] cyclization of nitroenynes and 3-pyrrolyloxindoles has been realized with a chiral bifunctional squaramide catalyst. This Michael/Friedel-Crafts cascade strategy provides a facile and efficient access to enantioenriched polycyclic aza-spirooxindoles with 32-95% isolated yields and excellent stereocontrol under mild reaction conditions.

Catalytic Asymmetric Halogenation/Semipinacol Rearrangement of 3-Hydroxyl-3-vinyl Oxindoles: A Stereodivergent Kinetic Resolution Process

A highly enantioselective halogenation/semipinacol rearrangement of isatin-derived allylic alcohols has been developed with a chiral N,N′-dioxide/ScIII complex as catalyst. This strategy involved a pivotal stereodivergent kinetic resolution process and provided a facile and efficient entry to optically active halo-substituted quinolone derivatives and quinoline alkaloids with a quaternary stereocenter simultaneously under mild reaction conditions. Based on the control experiments together with kinetic studies and DFT calculations, a possible catalytic cycle was proposed to illustrate the reaction process and enantiocontrol.

Asymmetric Conjugate Addition of Ethylene Sulfonyl Fluorides to 3-Amido-2-oxindoles: Synthesis of Chiral Spirocyclic Oxindole Sultams

An enantioselective conjugate addition of ethylene sulfonyl fluorides to 3-amido-2-oxindoles has been developed. Quinine-derived squaramides were identified as efficient catalysts. A series of spirocyclic oxindole sultams were prepared with excellent yields and enantioselectivities. A reaction mechanism via bifunctional activation was proposed.