940890-71-1

Basic information

• Product Name: 3-(3-methoxy-4-methyl-phenyl)acrylic acid methyl ester
• Synonyms: 3-(3-methoxy-4-methyl-phenyl)acrylic acid methyl ester
• CAS NO: 940890-71-1
• Molecular Weight: 206.241
• Mol File: 940890-71-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(3-methoxy-4-methyl-phenyl)acrylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-methoxy-4-methyl-phenyl)acrylic acid methyl ester(940890-71-1)
• EPA Substance Registry System: 3-(3-methoxy-4-methyl-phenyl)acrylic acid methyl ester(940890-71-1)

Safety Data

• Hazardous Substances Data: 940890-71-1(Hazardous Substances Data)

Upstream product

• 24973-22-6 3-methoxy-4-methylbenzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 209286-01-1 6-Methoxy-7-methyl-2H-isoquinolin-1-one 
• 1427527-68-1 C₁₁H₁₁NO₂ 
• 940890-82-4 6-hydroxy-7-methyl-2H-isoquinolin-1-one 
• 209287-19-4 ferulic acid 

Relevant articles and documents

6-SUBSTITUTED ISOQUINOLINE DERIVATIVES

The present invention relates to 6-substituted isoquinoline derivatives having the general Formula I wherein X is O, S or NH; Y is OH or NH2; m is 0, 1 or 2; n is 0 or 1; o is 0 or 1; R1 is H, when Y is NH2; or R1 is H, (C1-4)alkyl or halogen, when Y is OH; R2 and R3 are independently H, (C1-4)alkyl or halogen; R4 is H or (C1-6)alkyl, optionally substituted with halogen, (C3-7)cycloalkyl, (C6-10)aryl or a saturated 5- or 6-membered heterocyclic ring comprising 1-3 heteroatoms independently selected from O, S and N, the (C6-10)aryl and heterocyclic ring being optionally substituted with (C1-4)alkyl, (C1-4)alkyloxy or halogen; R5 is H or (C1-4)alkyl; or a pharmaceutically acceptable salt thereof, with the proviso that the compounds of Formula I wherein X is O, Y is OH , n is 0 and m+o=2 are excluded, to pharmaceutical compositions comprising the same, as well as to the use of said 6-substituted isoquinoline derivatives for the preparation of a medicament for the treatment of ROCK-I related disorders such as glaucoma, hypertension and atherosclerosis.

ISOQUINOLINE DERIVATIVES

The invention relates to isoquinoline derivatives having the general Formula (I) wherein X is O, S or NH; Y is OH or NH2; m is 0, 1 or 2; n is 1 or 2; R1 is H, when Y is NH2; or R1 is H, (C1-4)alkyl or halogen, when Y is OH; R2 and R3 are independently H, (C1-4)alkyl or halogen; R is H or (C1-6)alkyl, optionally substituted with OH, (C1-4)- alkyloxy, (C1-4)alkyloxycarbonyl, (C3-7)cycloalkyl, which may optionally comprise a heteroatom selected from O and S, (C6-10)aryl, (C6-10)aryloxy or a 5- or 6-membered heteroaryl group comprising 1-3 heteroatoms independently selected from O, N and S, each aryl or heteroaryl group being optionally substituted with 1-3 substituents independently selected from (C1-4)alkyl, (C1-4)alkyloxy, (C1-4)alkylsulfonyl and halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same as well as to the use of the isoquinoline derivatives in the treatment of ROCK-I related disorders such as hypertension, atherosclerosis and glaucoma.