941294-58-2

Basic information

• Product Name: t-butyl 6-bromo-3-pyridinecarboxylate
• Synonyms: t-Butyl 2-bromo-5-pyridinecarboxylate;t-butyl 6-bromo-3-pyridinecarboxylate;tert-Butyl 6-bromonicotinate;6-bromonicotinic acid tert-butyl ester;(tert-Butyl)6-bromonicotinate98%
• CAS NO: 941294-58-2
• Molecular Formula: C₁₀H₁₂BrNO₂
• Molecular Weight: 258.11
• Product Categories: blocks;Bromides;Pyridines
• Mol File: 941294-58-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 307.9°C at 760 mmHg
• Flash Point: 140ºC
• Appearance: /
• Density: 1.385g/cm3
• Vapor Pressure: 0.000702mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Keep Cold
• PKA: -1.22±0.10(Predicted)
• CAS DataBase Reference: t-butyl 6-bromo-3-pyridinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: t-butyl 6-bromo-3-pyridinecarboxylate(941294-58-2)
• EPA Substance Registry System: t-butyl 6-bromo-3-pyridinecarboxylate(941294-58-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 941294-58-2(Hazardous Substances Data)

Usage

General Description

T-butyl 6-bromo-3-pyridinecarboxylate is a chemical compound with the molecular formula C11H13BrNO2. It is a derivative of pyridine and belongs to the class of carboxylate esters. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a white solid with a molecular weight of 273.13 g/mol and is soluble in organic solvents such as methanol, ethanol, and dichloromethane. T-butyl 6-bromo-3-pyridinecarboxylate has potential applications in the field of medicinal chemistry and drug discovery, making it a valuable compound for research and development purposes.

InChI:InChI=1/C10H12BrNO2/c1-10(2,3)14-9(13)7-4-5-8(11)12-6-7/h4-6H,1-3H3

Upstream product

• 6311-35-9 6-bromonicotinic acid 
• 865-47-4 potassium tert-butylate 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 624-28-2 2,5-dibromopyridine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1033844-92-6 tert-butyl 6-(2-fluorophenyl)nicotinate 
• 1033844-91-5 tert-butyl 6-(2,5-difluorophenyl)nicotinate 
• 1033844-88-0 tert-butyl 6-(3,5-difluorophenyl)nicotinate 
• 1033843-85-4 tert-butyl 6-[4-({[6-(3-fluorophenyl)pyridin-3-yl]carbonyl}amino)piperidin-1-yl]nicotinate 
• 1033844-89-1 6-(3,5-difluoro-phenyl)-nicotinic acid 

Relevant articles and documents

AMIDE COMPOUND HAVING BET PROTEOLYSIS-INDUCING ACTION AND MEDICINAL APPLICATION THEREOF

The present invention aims to provide a compound that: has an excellent cytotoxic action on cancer cells, excellent induction of BET protein degradation in cancer cells, and an excellent binding-inhibiting action on BET protein and acetylated histone; and is effective as an anti-cancer agent, a BET protein degradation-inducing agent, or a BET protein inhibiting agent. A compound indicated in general formula (I) or a pharmacologically acceptable salt thereof. {In the formula, each symbol is as outlined in the Description.}

SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS

Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

NICOTINAMIDE DERIVATIVES

The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are defined herein, to compositions containing such compounds and to the uses of such compounds for the trea