94139-36-3

Basic information

• Product Name: 4-amino-N-(5-bromo-3-methoxy-pyrazin-2-yl)-benzenesulfonamide
• CAS NO: 94139-36-3
• Molecular Weight: 359.203
• Mol File: 94139-36-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-amino-N-(5-bromo-3-methoxy-pyrazin-2-yl)-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-N-(5-bromo-3-methoxy-pyrazin-2-yl)-benzenesulfonamide(94139-36-3)
• EPA Substance Registry System: 4-amino-N-(5-bromo-3-methoxy-pyrazin-2-yl)-benzenesulfonamide(94139-36-3)

Safety Data

• Hazardous Substances Data: 94139-36-3(Hazardous Substances Data)

Upstream product

• 95516-10-2 4-acetylamino-N-(5-bromo-3-methoxy-pyrazin-2-yl)-benzenesulfonamide 
• 5900-13-0 5-bromo-3-methoxypyrazin-2-amine 
• 4774-10-1 2-amino-3-methoxypyrazine 

Relevant articles and documents

Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein

Through high-throughput screening of 200000 compounds and subsequent structure-activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small molecule inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z). Applying a forward chemical genetic approach, we utilized an NSA based chemical probe to further reveal that NSA selectively targeted the Mixed Lineage Kinase Domain-like Protein (MLKL) to block the necrosome formation.