941587-68-4

Basic information

• Product Name: 7(S)-7-deoxy-7-(4-methoxycarbonylphenylthio)lincomycin
• Synonyms: 7(S)-7-deoxy-7-(4-methoxycarbonylphenylthio)lincomycin
• CAS NO: 941587-68-4
• Molecular Weight: 556.745
• Mol File: 941587-68-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7(S)-7-deoxy-7-(4-methoxycarbonylphenylthio)lincomycin(CAS DataBase Reference)
• NIST Chemistry Reference: 7(S)-7-deoxy-7-(4-methoxycarbonylphenylthio)lincomycin(941587-68-4)
• EPA Substance Registry System: 7(S)-7-deoxy-7-(4-methoxycarbonylphenylthio)lincomycin(941587-68-4)

Safety Data

• Hazardous Substances Data: 941587-68-4(Hazardous Substances Data)

Upstream product

• 941585-09-7 7-O-methanesulfonyl-2,3,4-tris-O-(trimethylsilyl)lincomycin 
• 6302-65-4 methyl 4-mercaptobenzoate 
• 25420-97-7 2,3,4-tris-O-(trimethylsilyl)lincomycin 
• 154-21-2 lincomycin 

Downstream Products

• 941588-35-8 7-deoxy-7-epi-7-(4-hydroxymethyl-phenylthio)-lincomycin 
• 941588-47-2 7-deoxy-7-epi-7-(4-(piperazinocarbonyl)-phenylthio)-lincomycin 
• 941588-29-0 7(S)-7-deoxy-7-(4-pyrrolidinocarbonylphenylthio)lincomycin 
• 941588-28-9 7(S)-7-deoxy-7-(4-dimethylcarbamoylphenylthio)lincomycin 
• 941588-41-6 7(S)-7-deoxy-7-(4-morpholinocarbonylphenylthio)lincomycin 

Relevant articles and documents

Synthesis and structure-activity relationships of novel lincomycin derivatives. Part 1. Newly generated antibacterial activities against Gram-positive bacteria with erm gene by C-7 modification

We synthesized 7(S)-7-deoxy-7-arylthiolincomycin derivatives possessing a heterocyclic ring at the C-7 position via sulfur atom by either Mitsunobu reaction of 2,3,4-tris-O-(trimethylsiliyl)lincomycin or S N 2 reaction of 7-O-methanesulfonyl-2,3,4-tri-O-t

LINCOMYCIN DERIVATIVE AND ANTIBACTERIAL AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT

This invention provides compounds of formula (I) or its pharmacologically acceptable salt or solvate, wherein A represents aryl or a monocyclic or bicyclic heterocyclic group, R1 represents a halide, nitro, substituted C1-6 alkyl, optionally substituted amino, C1-6 alkyloxycarbonyl, optionally substituted aryl, a heterocyclic group, or heterocyclic carbonyl, R2 represents a hydrogen atom or C1-6 alkyl, R3 represents C1-6 alkyl, all of R4, R5, and R6 represent a hydrogen atom, R7 represents C1-6 alkyl, m is 1 or 2, and n is 1. The compounds are novel lincomycin derivatives having a potent activity against resistant pneumococci. The compounds can be used as an antimicrobial agent and are useful for preventing or treating bacterial infectious diseases.