942185-01-5

Basic information

• Product Name: 1H-PYRAZOLO[3,4-B]PYRIDIN-5-AMINE
• Synonyms: 1H-PYRAZOLO[3,4-B]PYRIDIN-5-AMINE;1H-Pyrazolo[3,4-b]pyridin-5-ylamine;5-AMino-1H-pyrazolo[3,4-b...;5-AMino-1H-pyrazolo[3,4-b]pyridine;1H-Pyrazolo[3,4-b]pyridin-5-ylamine HCl
• CAS NO: 942185-01-5
• Molecular Formula: C₆H₆N₄
• Molecular Weight: 134.14
• Mol File: 942185-01-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 388.3±22.0 °C(Predicted)
• Appearance: /
• Density: 1.480±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.43±0.40(Predicted)
• CAS DataBase Reference: 1H-PYRAZOLO[3,4-B]PYRIDIN-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRAZOLO[3,4-B]PYRIDIN-5-AMINE(942185-01-5)
• EPA Substance Registry System: 1H-PYRAZOLO[3,4-B]PYRIDIN-5-AMINE(942185-01-5)

Safety Data

• Hazardous Substances Data: 942185-01-5(Hazardous Substances Data)

Usage

General Description

1H-Pyrazolo[3,4-b]pyridin-5-amine is a heterocyclic organic compound that falls under the category of pyrazolopyridines. In terms of structural properties, it contains a pyrazole ring attached to a pyridine ring, with an amine group attached to the fifth carbon in the pyridine ring. Because of its structure, it exhibits uniqueness in chemical behavior and finds valuable uses in medicinal chemistry. As an active intermediate in pharmaceuticals and agrochemicals, it plays an important role in designing potent bioactive molecules. However, as with all chemicals, detailed safety precautions must be observed in handling this compound to avoid potential risks.

Upstream product

• 1186608-67-2 tert-butyl 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[3,4-b]pyridin-5-ylcarbamate 
• 63572-73-6 5-nitropyrazolo<3,4-b>pyridine 

Downstream Products

• 1421429-85-7 phenyl 1H-pyrazolo[3,4-b]pyridin-5-ylcarbamate 
• 1186607-83-9 6-chloro-2-fluoro-3-(propylsulfonamido)-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide 
• 1186606-87-0 2,6-difluoro-3-(propylsulfonamido)-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide 

Relevant articles and documents

Development of 2, 4-diaminoquinazoline derivatives as potent PAK4 inhibitors by the core refinement strategy

Upon analysis of the reported crystal structure of PAK4 inhibitor KY04031 (PAK4 IC50?=?0.790?μM) in the active site of PAK4, we investigated the possibility of changing the triazine core of KY04031 to a quinazoline. Using KY04031 as a starting

Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands

Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds, and a method of using these compounds in the treatment and/or inhibition of pain and further diseases and/or disorders mediated at least in part via the vanilloid receptor 1 (VR1/TRPV1).

POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS

Disclosed are the ERK inhibitors of formula 1.0 and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.