94224-92-7

Basic information

• Product Name: methyl 4-(iodomethyl)benzoate
• Synonyms: methyl 4-(iodomethyl)benzoate
• CAS NO: 94224-92-7
• Molecular Weight: 276.074
• Mol File: 94224-92-7.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: methyl 4-(iodomethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(iodomethyl)benzoate(94224-92-7)
• EPA Substance Registry System: methyl 4-(iodomethyl)benzoate(94224-92-7)

Safety Data

• Hazardous Substances Data: 94224-92-7(Hazardous Substances Data)

Upstream product

• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 1571-08-0 methyl 4-formylbenzoate 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 34040-64-7 p-methyloxycarbonylbenzyl chloride 
• 1642-81-5 p-(chloromethyl)benzoic acid 
• 876-08-4 p-(chloromethyl)benzoyl chloride 
• 619-66-9 4-Carboxybenzaldehyde 

Downstream Products

• 99-75-2 4-methyl-benzoic acid methyl ester 
• 797-21-7 1,2-bis(4-methoxycarbonylphenyl)ethane 
• 94224-93-8 1-<<4-(methoxycarbonyl)benzyl>azonia>-8,15,22-triazatricyclo<13.13.6.6^8,22>tetracontane iodide 
• 247017-89-6 methyl 4-(((bis(benzyloxy)phosphoryl)oxy)methyl)benzoate 
• 950745-56-9 C₂₇H₄₂Si₂O₃ 
• 950746-04-0 (Z)-4-[3,4-bis(tert-butyldimethylsilyloxy)styryl]phenylmethanol 
• 950745-58-1 4-{2-[3,4-bis-(tert-butyldimethyl-silanyloxy)-phenyl]-vinyl}-benzaldehyde 
• 950746-02-8 (Z)-4-[3,4-bis(tertbutyldimethylsilyloxy)styryl]benzaldehyde 
• 950745-54-7 trans-3,4-di-(tert-butyldimethylsilanyloxy)-4'-(methoxycarbonyl)stilbene 
• 950745-69-4 cis-3,4-di-(tertbutyldimethylsilanyloxy)-4'-(methoxycarbonyl)stilbene 

Relevant articles and documents

Conversion of Aryl Aldehydes to Benzyl Iodides and Diarylmethanes by H3PO3/I2

For the first time, H3PO3 was used as both the reducing reagent and the promotor in the reductive benzylation reactions with aryl aldehydes. By using a H3PO3/I2 combination, various aromatic aldehydes underwent iodination reactions and Friedel-Crafts type reactions with arenes via benzyl iodide intermediates, readily producing benzyl iodides and diarylmethanes in good yields. Intramolecular cyclization reactions also took place, giving the corresponding cyclic compounds. This new strategy features easy-handling, low-cost, and metal-free conditions.

RAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS

Provided herein are RAS protein degraders, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a RAS-mediated disorder, disease, or condition.

Discovery and preliminary structure–activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties

Indoleamine 2,3-dioxygenase 1 (IDO1)-mediated kynurenine pathway of tryptophan degradation is identified as an important immune effector pathway in the tumor cells to escape a potentially effective immune response. IDO1 is an attractive target for anticancer therapy and the discovery of IDO1 inhibitors has been intensely ongoing in both academic research laboratories and pharmaceutical organizations. Our study discovered that 1H-indazole was a novel key pharmacophore with potent IDO1 inhibitory activity. A series of new 1H-indazole derivatives were synthesized and determined the enzyme inhibitory activities, and the compound 2g exhibited the highest activity with an IC50value of 5.3 μM. The structure–activity relationships (SARs) analysis of the 1H-indazole derivatives as novel IDO1 inhibitors indicated that the 1H-indazole scaffold is necessary for IDO1 inhibition, and the substituent groups at the both 4-position and 6-position largely affect inhibitory activity. The docking model exhibited that the effective interactions of 1H-indazoles with ferrous ion of heme and key residues of hydrophobic Pocket A and B ensured the IDO1 inhibitory activities. The study suggested that the 1H-indazole was a novel interesting scaffold for IDO inhibition for further development.