942511-70-8

Basic information

• Product Name: 6-Chloro-5-methyl-nicotinic acid ethyl ester
• Synonyms: 6-Chloro-5-methyl-nicotinic acid ethyl ester;Ethyl6-chloro-5-methylpyridine-3-carboxylate;Ethyl 6-chloro-5-methylnicotinate
• CAS NO: 942511-70-8
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.64
• Mol File: 942511-70-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Chloro-5-methyl-nicotinic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-5-methyl-nicotinic acid ethyl ester(942511-70-8)
• EPA Substance Registry System: 6-Chloro-5-methyl-nicotinic acid ethyl ester(942511-70-8)

Safety Data

• Hazardous Substances Data: 942511-70-8(Hazardous Substances Data)

Usage

Type of Compound

Ester derivative

Parent Compound

6-chloro-5-methyl-nicotinic acid

Applications

Used in the synthesis of pharmaceuticals and agrochemicals

Biological Activities

Potential medicinal and agricultural applications

Usage

Building block in the synthesis of bioactive compounds

Value

Valuable intermediate for drug and agricultural product development

Potential Uses

Research tool in organic chemistry and drug discovery

Upstream product

• 4403-61-6 2-methyl-2-butene nitrile 
• 30574-97-1 tiglonitrile 
• 176433-43-5 6-chloro-5-methylpyridine-3-carboxaldehyde 
• 85614-89-7 6-hydroxy-5-methyl-nicotinic acid ethyl ester 
• 64-17-5 ethanol 
• 66909-29-3 6-chloro-5-methylpyridin-3-ylcarboxylic acid 

Downstream Products

• 1186617-39-9 5-methyl-6-pyrrolidin-1-yl-nicotinic acid 
• 1186618-27-8 C₂₄H₃₁N₅O₃ 
• 1186617-62-8 2-ethyl-6-methyl-4-[5-(5-methyl-6-pyrrolidin-1-yl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-phenol 
• 1186618-30-3 N-((S)-3-{2-ethyl-6-methyl-4-[5-(5-methyl-6-pyrrolidin-1-yl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]phenoxy}-2-hydroxypropyl)-2-hydroxyacetamide 
• 1186617-59-3 N-((S)-3-{4-[5-(6-diethylamino-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide 

Relevant articles and documents

Novel S1P1 receptor agonists - Part 3: From thiophenes to pyridines

In preceding communications we summarized our medicinal chemistry efforts leading to the identification of potent, selective, and orally active S1P 1 agonists such as the thiophene derivative 1. As a continuation of these efforts, we replaced the thiophene in 1 by a 2-, 3-, or 4-pyridine and obtained less lipophilic, potent, and selective S1P1 agonists (e.g., 2) efficiently reducing blood lymphocyte count in the rat. Structural features influencing the compounds' receptor affinity profile and pharmacokinetics are discussed. In addition, the ability to penetrate brain tissue has been studied for several compounds. As a typical example for these pyridine based S1P 1 agonists, compound 53 showed EC50 values of 0.6 and 352 nM for the S1P1 and S1P3 receptor, respectively, displayed favorable PK properties, and penetrated well into brain tissue. In the rat, compound 53 maximally reduced the blood lymphocyte count for at least 24 h after oral dosing of 3 mg/kg.

NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES

The invention relates to novel pyrimidine-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

Pyridin-3-yl derivatives as immunomodulating agents

The invention relates to pyridin-3-yl derivatives of Formula (I) wherein R1, R2, R3, R4, R5; R6 and A are as described in the description, their preparation and their use as pharmaceuticall