942589-57-3

Basic information

• Product Name: methyl 3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-phenyl-2-thiophenecarboxylate
• Synonyms: methyl 3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-phenyl-2-thiophenecarboxylate
• CAS NO: 942589-57-3
• Molecular Weight: 399.554
• Mol File: 942589-57-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-phenyl-2-thiophenecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-phenyl-2-thiophenecarboxylate(942589-57-3)
• EPA Substance Registry System: methyl 3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-phenyl-2-thiophenecarboxylate(942589-57-3)

Safety Data

• Hazardous Substances Data: 942589-57-3(Hazardous Substances Data)

Upstream product

• 55930-23-9 trans-4-methylcyclohexanecarbonyl chloride 
• 478028-16-9 methyl 3-(isopropyl-amino)-5-phenylthiophene-2-carboxylate 
• 934-67-8 trans-4-methylcyclohexanecarboxylic acid 

Relevant articles and documents

3-CARBONYLAMINOTHIOPHENE-2-CARBOXYLIC ACIDS AS HEPATITIS C VIRUS INHIBITORS

The present invention relates to novel 2-carboxy thiophene compounds of the formula (I): and salts thereof, to pharmaceutical compositions containing them and their use in medicine, as anti-viral agents. Specifically, the present invention relates to comp

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides

Further SAR studies on the thiophene-2-carboxylic acids are reported. These studies led to the identification of a series of tertiary amides that show inhibition of both HCV NS5B polymerase in vitro and HCV subgenomic RNA replication in Huh-7 cells. Structural insights about the bioactive conformation of this class of molecules were deduced from a combination of modeling and transferred NOE (trNOE) studies.