94266-06-5

Basic information

• Product Name: diethyl 4-butyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate
• Synonyms: diethyl 4-butyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate;2,6-Dimethyl-4-butyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester;4-Butyl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester;4-Butyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
• CAS NO: 94266-06-5
• Molecular Formula: C₁₇H₂₇NO₄
• Molecular Weight: 309.40058
• EINECS: 304-412-4
• Mol File: 94266-06-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 403.2°Cat760mmHg
• Flash Point: 197.7°C
• Appearance: /
• Density: 1.031g/cm³
• Vapor Pressure: 1.04E-06mmHg at 25°C
• Refractive Index: 1.477
• CAS DataBase Reference: diethyl 4-butyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 4-butyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate(94266-06-5)
• EPA Substance Registry System: diethyl 4-butyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate(94266-06-5)

Safety Data

• Hazardous Substances Data: 94266-06-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H27NO4/c1-6-9-10-13-14(16(19)21-7-2)11(4)18-12(5)15(13)17(20)22-8-3/h13,18H,6-10H2,1-5H3

Upstream product

• 110-62-3 pentanal 
• 141-97-9 ethyl acetoacetate 
• 626-34-6 ethyl 3-aminobut-2-enoate 
• 631-61-8 ammonium acetate 
• 123-72-8 butyraldehyde 
• 506-87-6 ammonium carbonate 

Downstream Products

• 52884-95-4 2-oxo-N-phenylhexanamide 

Relevant articles and documents

Manganese(III)-Promoted Double Carbonylation of Anilines Toward α-Ketoamides Synthesis

Employing anilines as nucleophiles in double carbonylation is a longstanding challenge. In this communication, a Mn(III)-promoted double carbonylation of alkylborates or Hantzsch esters with anilines toward the synthesis of α-ketoamides has been developed. By using easily available potassium alkyltrifluoroborates or Hantzsch esters as the starting material, and cheap and non-toxic Mn(OAc)3 ? 2H2O as the promotor, a broad range of alkyl α-ketoamide derivatives were synthesized in moderate to good yields with excellent selectivity. (Figure presented.).

Synthesis of diethyl 4-substituted-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates as a new series of inhibitors against yeast α-glucosidase

1,4-Dihydropyridine-3,5-dicarboxylate derivatives (1-25) were synthesized in high yields via Hantzsch reaction and evaluated for their α-glucosidase inhibitory activity. Compounds 1, 2, 6-8, 11, 13-15, and 23-25 showed a potent inhibitory activity against yeast α-glucosidase with IC50 values in the range of 35.0-273.7 μM, when compared with the standard drug acarbose (IC50 = 937 ± 1.60 μM). Their structures were characterized by different spectroscopic techniques. The kinetics, selectivity, and toxicity studies on these compounds were also carried out. The kinetic studies on most active compounds 14 and 25 determined their modes of inhibition and dissociation constants Ki. Compound 14 was found to be a non-competitive inhibitor with Ki = 25.0 ± 0.06, while compound 25 was identified as a competitive inhibitor with Ki = 66.0 ± 0.07 μM.