94306-39-5Relevant articles and documents
RORγ MODULATORS
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Page/Page column 22; 57-58, (2018/04/13)
The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.
Novel palladium-catalyzed atom-efficient cross-coupling reaction by means of hexaarylcyclotrisiloxane
Endo, Mayuko,Sakurai, Tomoyuki,Ojima, Satoshi,Katayama, Takako,Unno, Masafumi,Matsumoto, Hideyuki,Kowase, Susumu,Sano, Hiroshi,Kosugi, Masanori,Fugami, Keigo
, p. 749 - 752 (2008/01/08)
Hexaarylcyclotrisiloxane, which is one of the most stable derivatives of diarylsilanediol, was found to undergo palladium-catalyzed cross-coupling reaction with aryl halides in good yields. The reaction is performed in an aqueous medium taking potassium hydroxide as an activator. Both of the two aryl groups attached to each silicon atom could be utilized. Some base-sensitive functionality such as acetyl and nitro groups survived the reaction. Georg Thieme Verlag Stuttgart.