94319-79-6

Basic information

• Product Name: N-(2-AMINOETHYL)-4-CHLOROBENZAMIDE HYDROCHLORIDE
• Synonyms: RO 16-6491;N-(2-AMINOETHYL)-4-CHLOROBENZAMIDE HCL;N-(2-AMINOETHYL)-4-CHLOROBENZAMIDE HYDROCHLORIDE;Zinc02555368
• CAS NO: 94319-79-6
• Molecular Formula: C9H12Cl2N2O
• Molecular Weight: 235.11
• Product Categories: Heterocyclic Compounds;Inhibitors;Neurochemicals;Amines;Aromatics
• Mol File: 94319-79-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 209-210°C
• Boiling Point: 404.2 °C at 760 mmHg
• Flash Point: 198.2 °C
• Appearance: white/solid
• Vapor Pressure: 6.31E-07mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: H2O: soluble
• Stability: Store in Freezer at -20°C
• CAS DataBase Reference: N-(2-AMINOETHYL)-4-CHLOROBENZAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMINOETHYL)-4-CHLOROBENZAMIDE HYDROCHLORIDE(94319-79-6)
• EPA Substance Registry System: N-(2-AMINOETHYL)-4-CHLOROBENZAMIDE HYDROCHLORIDE(94319-79-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 94319-79-6(Hazardous Substances Data)

Usage

Description

N-(2-AMINOETHYL)-4-CHLOROBENZAMIDE HYDROCHLORIDE is a white solid that functions as a competitive, time-dependent reversible inhibitor of monamine oxidase-B (MAO-B) and is an analogue of N-(2-Aminoethyl)benzamide.

Uses

Used in Pharmaceutical Industry:
N-(2-AMINOETHYL)-4-CHLOROBENZAMIDE HYDROCHLORIDE is used as a pharmaceutical agent for its inhibitory effect on monamine oxidase-B (MAO-B), which plays a significant role in the regulation of neurotransmitter levels in the brain. This makes it a potential candidate for the treatment of neurological and psychiatric disorders associated with monoamine neurotransmitters.
Used in Research Applications:
In research settings, N-(2-AMINOETHYL)-4-CHLOROBENZAMIDE HYDROCHLORIDE serves as a valuable tool for studying the function and mechanisms of MAO-B enzymes. Its reversible inhibitory properties allow scientists to modulate enzyme activity in a controlled manner, facilitating a better understanding of the enzyme's role in various biological processes and the development of novel therapeutic strategies.

InChI:InChI=1/C9H11ClN2O.ClH/c10-8-3-1-7(2-4-8)9(13)12-6-5-11;/h1-4H,5-6,11H2,(H,12,13);1H

Upstream product

• 94319-80-9 tert-butyl (2-(4-chlorobenzamido)ethyl)carbamate 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 122-01-0 4-chloro-benzoyl chloride 
• 541-41-3 chloroformic acid ethyl ester 
• 74-11-3 para-chlorobenzoic acid 
• 94320-01-1 N-(2-acetylaminoethyl)-4-chlorobenzamide 
• 107-15-3 ethylenediamine 

Downstream Products

• 1252886-53-5 cis-4-[4-({2-[(4-chlorobenzoyl)amino]ethyl}carbamoyl)-3-methoxyphenoxy]cyclohexanecarboxylic acid 
• 1252898-77-3 ethyl cis-4-[4-({2-[(4-chlorobenzoyl)amino]ethyl}carbamoyl)-3-fluorophenoxy]cyclohexanecarboxylate 

Relevant articles and documents

NOVEL ARGINASE INHIBITORS

The present invention relates to novel arginase inhibitors of formula (I). These novel compounds are useful in the treatment of diseases that are associated with arginase activity, such as asthma, allergic rhinitis and COPD (chronic obstructive pulmonary disease).

New analogues of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators

A series of halo- and nitro-substituted analogues of N-(2- aminoethyl)benzamide has been synthesized. All of the compounds are competitive, time-dependent inhibitors of monoamine oxidase-B (MAO-B), but upon dialysis complete return of enzyme activity is observed for all compounds. Therefore, these are mechanism-based reversible inhibitors of MAO- B. The relative potencies of the compounds are rationalized in terms of steric and hydrophobic effects.