943518-63-6

Basic information

• Product Name: Itopride Impurity A
• Synonyms: Itopride Impurity A;Itopride Impurity 1;Benzamide, N-[(4-hydroxyphenyl)methyl]-3,4-dimethoxy-
• CAS NO: 943518-63-6
• Molecular Formula: C₁₆H₁₇NO₄
• Molecular Weight: 287.31
• EINECS: -0
• Mol File: 943518-63-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 483.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.212±0.06 g/cm3(Predicted)
• PKA: 9.69±0.15(Predicted)
• CAS DataBase Reference: Itopride Impurity A(CAS DataBase Reference)
• NIST Chemistry Reference: Itopride Impurity A(943518-63-6)
• EPA Substance Registry System: Itopride Impurity A(943518-63-6)

Safety Data

• Hazardous Substances Data: 943518-63-6(Hazardous Substances Data)

Usage

General Description

Itopride Impurity A is a chemical related to the drug itopride, which is used to treat gastrointestinal disorders. It is a known impurity that can be found in itopride formulations, and its presence in the drug substance may need to be monitored and controlled to ensure the quality and safety of the medication. Itopride Impurity A can be characterized and quantified using various analytical techniques, and its levels should be kept within specified limits to meet regulatory requirements and quality standards for itopride pharmaceutical products. Regular testing and monitoring for the presence of Itopride Impurity A are important to ensure the safety and efficacy of itopride formulations for patient use.

Upstream product

• 696-60-6 4-aminomethylphenol 
• 93-07-2 Veratric acid 
• 50-00-0 formaldehyd 
• 1521-41-1 veratramide 
• 108-95-2 phenol 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 

Downstream Products

• 122898-67-3 itopride 
• 122892-31-3 N-<4-<2-(dimethylamino)ethoxy>benzyl>-3,4-dimethoxybenzamide hydrochloride 

Relevant articles and documents

Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow

Phosphine-mediated deoxygenative nucleophilic substitutions, such as the Mitsunobu reaction, are of great importance in organic synthesis. However, the conventional protocols require stoichiometric oxidants to trigger the formation of the oxyphosphonium i

Preparation method of itopride hydrochloride

The invention relates to a preparation method of itopride hydrochloride and belongs to the technical field of raw material preparation. The technical scheme is as follows: the preparation method of itopride hydrochloride comprises the steps as follows: an intermediate I is prepared from initial materials including 3,4-dimethoxybenzamide, formaldehyde and phenol with a one-pot method; the intermediate I and N,N-dimethyl chloroethane hydrochloride are subjected to a substitution reaction to produce an intermediate II; finally, itopride hydrochloride is prepared through salification. The itopridepreparation process comprises a short and convenient route and is economical and environmentally friendly.

NOVEL PROCESS FOR SYNTHESIS OF ITOPRIDE AND ITS NOVEL INTERMEDIATE N-(4-HYDROXYBENZYL)- 3,4-DIMETHOXYBENZAMIDE

The present invention relates to a novel and improved process for the preparation of N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide—known as Itopride, via a novel intermediate N-(4?hydroxybenzyl)-3,4-dimethoxybenzamide.