943541-39-7

Basic information

• Product Name: Difluoro-quinolin-6-yl-acetic acid hydrazide
• Synonyms: Difluoro-quinolin-6-yl-acetic acid hydrazide;2,2-difluoro-2-quinolin-6-ylacetohydrazide;2,2-DIFLUORO-2-(QUINOLIN-6-YL)ACETIC ACID HYDRAZIDE(WXG03028);2,2-DIFLUORO-2-(QUINOLIN-6-YL)ACETIC ACID HYDRAZIDE
• CAS NO: 943541-39-7
• Molecular Formula: C₁₁H₉F₂N₃O
• Molecular Weight: 237.2054664
• Mol File: 943541-39-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 459.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.387±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.90±0.50(Predicted)
• CAS DataBase Reference: Difluoro-quinolin-6-yl-acetic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Difluoro-quinolin-6-yl-acetic acid hydrazide(943541-39-7)
• EPA Substance Registry System: Difluoro-quinolin-6-yl-acetic acid hydrazide(943541-39-7)

Safety Data

• Hazardous Substances Data: 943541-39-7(Hazardous Substances Data)

Upstream product

• 1093204-29-5 ethyl 2-oxo-2-(6-quinolyl)acetate 
• 13327-31-6 6-iodoquinoline 
• 5332-25-2 6-bromoquinoline 
• 943541-40-0 ethyl 2,2-difluoro-2-(quinolin-6-yl)acetate 
• 943541-38-6 2,2-difluoro-2-(quinolin-6-yl)acetic acid methyl ester 

Downstream Products

• 943540-75-8 JNJ-38877605 
• 1151800-43-9 6-[(6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)-difluoro-methyl]-quinoline 

Relevant articles and documents

HETEROCYCLIC HYDRAZONE COMPOUNDS AND THEIR USES TO TREAT CANCER AND INFLAMMATION

The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITORS OF C-MET PROTEIN KINASE

The present invention relates to compounds of formula (I), which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula (I) and methods of using the compositions in the treatment of proliferative disorders

TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS

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