943764-99-6 Usage
Description
Acebilustat (also known as CTX-4430) is a new once-daily oral anti-inflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases. It is an inhibitor of leukotriene A4 hydrolase, which is responsible for the production of leukotriene B4 (LTB4). The later is a molecule that leads to inflammation. Therefore, Acebilustat can treat inflammation through suppressing the production of leukotriene B4.
References
https://www.cff.org/Trials/Pipeline/details/108/CTX-4430
Springman, E., et al. "127 Pharmacokinetic and pharmacodynamic profile of CTX-4430 in two phase 1 studies." Journal of Cystic Fibrosis14(2015):S90-S90.
Springman, E., et al. "126 A phase 1 clinical study of CTX-4430 in cystic fibrosis patients." Journal of Cystic Fibrosis 14(2015):S90-S90.
Elborn, J. S., et al. "Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction." Clinical & Translational Science 10.1(2017):20-27.
Check Digit Verification of cas no
The CAS Registry Mumber 943764-99-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,3,7,6 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 943764-99:
(8*9)+(7*4)+(6*3)+(5*7)+(4*6)+(3*4)+(2*9)+(1*9)=216
216 % 10 = 6
So 943764-99-6 is a valid CAS Registry Number.
943764-99-6Relevant articles and documents
Diamine derivatives as inhibitors of leukotriene A4 hydrolase
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Page/Page column 70-71, (2010/11/27)
This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9
