94385-68-9Relevant articles and documents
3-Arylpropionylhydroxamic acid derivatives as Helicobacter pylori urease inhibitors: Synthesis, molecular docking and biological evaluation
Shi, Wei-Kang,Deng, Rui-Cheng,Wang, Peng-Fei,Yue, Qin-Qin,Liu, Qi,Ding, Kun-Ling,Yang, Mei-Hui,Zhang, Hong-Yu,Gong, Si-Hua,Deng, Min,Liu, Wen-Run,Feng, Qiu-Ju,Xiao, Zhu-Ping,Zhu, Hai-Liang
, p. 4519 - 4527 (2016/09/13)
Helicobacter pylori urease is involved in several physiologic responses such as stomach and duodenal ulcers, adenocarcinomas and stomach lymphomas. Thus, inhibition of urease is taken for a good chance to treat H. pylori-caused infections, we have therefore focused our efforts on seeking novel urease inhibitors. Here, a series of arylpropionylhydroxamic acids were synthesized and evaluated for urease inhibition. Out of these compounds, 3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropionylhydroxamic acid (d24) was the most active inhibitor with IC50of 0.15?±?0.05?μM, showing a mixed inhibition with both competitive and uncompetitive aspects. Non-linear fitting of kinetic data gives kinetics parameters of 0.13 and 0.12?μg·mL?1for Kiand Ki′, respectively. The plasma protein binding assays suggested that d24 exhibited moderate binding to human and rabbit plasma proteins.
Arylpropane-1,3-diols in lignins from normal and CAD-deficient pines
Ralph, John,Kim, Hoon,Peng, Junpeng,Lu, Fachuang
, p. 323 - 326 (2008/02/12)
(equation presented) Significant quantities of arylpropane-1,3-diols have been identified in lignins isolated from a CAD-deficient pine mutant; smaller amounts are also present in lignins from normal pine. They arise from dihydroconiferyl alcohol via the action of peroxidases which are responsible for the radical generation steps of lignification. The structures in the complex lignin polymers are proven using 2D and 3D NMR of isolated lignin fractions.
