943937-28-8Relevant articles and documents
Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors
Holsworth, Daniel D.,Jalaie, Mehran,Belliotti, Thomas,Cai, Cuiman,Collard, Wendy,Ferreira, Suzie,Powell, Noel A.,Stier, Michael,Zhang, Erli,McConnell, Pat,Mochalkin, Igor,Ryan, Michael J.,Bryant, John,Li, Tingsheng,Kasani, Aparna,Subedi, Rajendra,Maiti, Samarendra N.,Edmunds, Jeremy J.
, p. 3575 - 3580 (2007)
Novel 2,4-diaminopyrimidine-based small molecule renin inhibitors are disclosed. Through high throughput screening, parallel synthesis, X-ray crystallography, and structure based drug design, we have developed the first non-chiral, non-peptidic, small mol