944054-46-0Relevant articles and documents
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N- methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors
Shao, Liming,Wang, Fengjiang,Malcolm, Scott C.,Ma, Jianguo,Hewitt, Michael C.,Campbell, Una C.,Bush, Larry R.,Spicer, Nancy A.,Engel, Sharon R.,Saraswat, Lakshmi D.,Hardy, Larry W.,Koch, Patrick,Schreiber, Rudy,Spear, Kerry L.,Varney, Mark A.
experimental part, p. 663 - 676 (2011/03/17)
The present work describes a series of novel chiral amines that potently inhibit the in vitro reuptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) and were active in vivo in a mouse model predictive of antidepressant like activi