944130-08-9Relevant articles and documents
Enantioselective total synthesis of phomallenic acid C
Jian, Ya-Jun,Tang, Chao-Jun,Wu, Yikang
, p. 4851 - 4855 (2008/02/05)
(Chemical Equation Presented) The newly isolated bacterial FAS II inhibitor phomallenic acid C (3) was synthesized for the first time as a 16:1 mixture of the (R)- and (S)-isomer with the diyne-allene motif constructed using a coupling under Negishi conditions. By comparison with the synthetic sample, the natural phomallenic acid C was estimated to be a 3.8:1 mixture of (R)-/(S)-isomers. This synthesis describes a new synthetic entry to optically active allene diynes.