944256-06-8

Basic information

• Product Name: [4-amino-4-(3,4-dimethoxyphenyl)butyl]carbamic acid tert-butyl ester
• Synonyms: [4-amino-4-(3,4-dimethoxyphenyl)butyl]carbamic acid tert-butyl ester
• CAS NO: 944256-06-8
• Molecular Weight: 324.42
• Mol File: 944256-06-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [4-amino-4-(3,4-dimethoxyphenyl)butyl]carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-amino-4-(3,4-dimethoxyphenyl)butyl]carbamic acid tert-butyl ester(944256-06-8)
• EPA Substance Registry System: [4-amino-4-(3,4-dimethoxyphenyl)butyl]carbamic acid tert-butyl ester(944256-06-8)

Safety Data

• Hazardous Substances Data: 944256-06-8(Hazardous Substances Data)

Upstream product

• 944256-05-7 [4-(3,4-dimethoxyphenyl)-4-oxo-butyl]carbamic acid tert-butyl ester 

Downstream Products

• 1190089-46-3 [4-(3,4-dimethoxyphenyl)-4-(4-hydroxy-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)butyl]carbamic acid tert-butyl ester 

Relevant articles and documents

Nonpeptide urotensin-II receptor antagonists: A new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits

We have discovered two related chemical series of nonpeptide urotensin-II (U-II) receptor antagonists based on piperazino-phthalimide (5 and 6) and piperazino-isoindolinone (7) scaffolds. These structure types are distinctive from those of U-II receptor antagonist series reported in the literature. Antagonist 7a exhibited single-digit nanomolar potency in rat and human cell-based functional assays, as well as strong binding to the human U-II receptor. In advanced pharmacological testing, 7a blocked the effects of U-II in vitro in a rat aortic ring assay and in vivo in a rat ear-flushmodel. Adiscussion of U-II receptor antagonist pharmacophores is presented, and a specifically defined model is suggested from tricycle 13, which has a high degree of conformational constraint.