944270-01-3Relevant articles and documents
Protected aminooxyprolines for expedited library synthesis: Application to Tsg101-directed proline-oxime containing peptides
Liu, Fa,Stephen, Andrew G.,Fisher, Robert J.,Burke Jr., Terrence R.
, p. 1096 - 1101 (2008/09/19)
The stereoselective synthesis of aminooxy-containing proline analogues bearing Fmoc/Boc or Fmoc/Mtt protection that renders them suitable for incorporation into peptides using Fmoc protocols is reported. Acid-catalyzed unmasking at the completion of peptide synthesis yields free aminooxy-functionalities for oxime formation through reaction with libraries of aldehydes. This allows post solid-phase diversification strategies that may facilitate structure-activity relationship studies.
