944342-88-5

Basic information

• Product Name: 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde
• Synonyms: 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde
• CAS NO: 944342-88-5
• Molecular Weight: 354.796
• Mol File: 944342-88-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde(944342-88-5)
• EPA Substance Registry System: 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde(944342-88-5)

Safety Data

• Hazardous Substances Data: 944342-88-5(Hazardous Substances Data)

Upstream product

• 144347-32-0 4-benzyloxy-3-chloroaniline 
• 14160-93-1 4-amino-6-chloro-pyrimidine-5-carbaldehyde 

Downstream Products

• 1044506-72-0 C₁₉H₁₈ClN₅O₂ 
• 944343-03-7 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carboxylic acid methyl ester 
• 944341-54-2 JNJ-28871063 

Relevant articles and documents

SUBSTITUTED PYRIMIDINE-5-CARBOXAMIDE AND 5-CARBOXYLIC ESTER KINASE INHIBITORS

The present invention is directed to substituted pyrimidine-5-carboxamide and 5-carboxylic ester compounds of Formula (I): and forms thereof wherein R1, R2, R3, R4, R5, R6, R7 and L are as defined herein and their synthesis and use as kinase inhibitors for treating a chronic or acute protein kinase mediated disease.

A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: Design, synthesis, and biological activity

A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine was synthesized and found to have potent dual EGFR/HER2 kinase inhibitory activity. The structure-based drug design of this molecule as well as the kinase and cellular inhibition of HER2 kinase dependent cell lines will be discussed.

SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS

The present invention is directed to substituted pyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.