94435-76-4

Basic information

• Product Name: Benzene, 1-(dodecylthio)-4-methyl-
• CAS NO: 94435-76-4
• Molecular Formula: C19H32S
• Molecular Weight: 292.529
• Mol File: 94435-76-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(dodecylthio)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(dodecylthio)-4-methyl-(94435-76-4)
• EPA Substance Registry System: Benzene, 1-(dodecylthio)-4-methyl-(94435-76-4)

Safety Data

• Hazardous Substances Data: 94435-76-4(Hazardous Substances Data)

Upstream product

• 10486-08-5 sodium p-thiocresolate 
• 151-21-3 sodium dodecyl-sulfate 
• 624-31-7 4-tolyl iodide 
• 112-55-0 1-dodecylthiol 
• 40390-88-3 dodecansulfenyl chloride 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 104-85-8 para-methylbenzonitrile 
• 103-19-5 di(p-tolyl) disulfide 
• 143-15-7 1-dodecylbromide 
• 10157-76-3 dodecyl 4-methylbenzenesulphonate 
• 106-45-6 para-thiocresol 

Downstream Products

• 148017-75-8 1-methyl-4-(dodecylsulfinyl)benzene 

Relevant articles and documents

Nickel-Catalyzed Thiolation of Aryl Nitriles

A nickel-catalyzed thiolation of aryl nitriles has been developed to access functionalized aryl thioethers. The ligand dcype (1,2-bis(dicyclohexylphosphino)ethane) as well as the base KOtBu (potassium tert-butoxide) are essential to achieve this transformation. This scalable and practical process involves both a C?C bond activation and a C?S bond formation. Furthermore, this reaction shows a high functional-group tolerance and enables the late-stage functionalization of important molecules.

Manganese-catalyzed cross-coupling of thiols with aryl iodides

A manganese-catalyzed cross-coupling reaction of thiols with aryl iodides, furnishing aryl thioethers in good to excellent yields has been reported; the system shows good functional group tolerance and enables the sterically demanding aryl iodides to couple with thiols. Coming up for ArI: A manganese-catalyzed cross-coupling reaction of thiols with aryl iodides that furnishes aryl thioethers in good to excellent yields has been reported. Functional groups such as unprotected alcohols and chloro substituents are tolerated under these reaction conditions. Moreover, this catalytic system enables the sterically demanding aryl iodides to couple with thiols (see scheme; R=aryl or alkyl).

Synthesis of aryl thioethers through the N -chlorosuccinimide-promoted cross-coupling reaction of thiols with Grignard reagents

A convenient one-pot approach for the synthesis of aryl sulfides through the coupling of thiols with Grignard reagents in the presence of N-chlorosuccinimide is described. The sulfenylchlorides were formed when thiols were treated with N-chlorosuccinimide, and the resulting sulfenylchlorides were then directly reacted with Grignard reagents to provide aryl sulfides in good to excellent yields under mild reaction conditions. Functional groups including ester, fluoro, and chloro are tolerated by the reaction conditions employed. It is important to note that this method has a short reaction time (30 min in total) and represents an alternative approach for the synthesis of aryl sulfides over the existing protocols.