944470-56-8

Basic information

• Product Name: (S)-TERT-BUTYL (1-(3-FLUOROPHENYL)-3-HYDROXYPROPAN-2-YL)CARBAMATE
• Synonyms: (S)-TERT-BUTYL (1-(3-FLUOROPHENYL)-3-HYDROXYPROPAN-2-YL)CARBAMATE;tert-butyl [(1S)-1-(3-fluorobenzyl)-2-hydroxyethyl]carbamate
• CAS NO: 944470-56-8
• Molecular Formula: C₁₄H₂₀FNO₃
• Molecular Weight: 269.3119032
• Mol File: 944470-56-8.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (S)-TERT-BUTYL (1-(3-FLUOROPHENYL)-3-HYDROXYPROPAN-2-YL)CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-TERT-BUTYL (1-(3-FLUOROPHENYL)-3-HYDROXYPROPAN-2-YL)CARBAMATE(944470-56-8)
• EPA Substance Registry System: (S)-TERT-BUTYL (1-(3-FLUOROPHENYL)-3-HYDROXYPROPAN-2-YL)CARBAMATE(944470-56-8)

Safety Data

• Hazardous Substances Data: 944470-56-8(Hazardous Substances Data)

Usage

Description

(S)-TERT-BUTYL (1-(3-FLUOROPHENYL)-3-HYDROXYPROPAN-2-YL)CARBAMATE is a chiral carbamate derivative with the molecular formula C13H19FNO3. It features a tert-butyl group attached to the nitrogen atom and a fluorophenyl group, which may contribute to its potential biological activity. Due to its structural similarity to other compounds that interact with biological targets, it holds promise for pharmaceutical applications, particularly in the development of new drugs targeting enzymes, receptors, or proteins involved in various biological processes.

Uses

Used in Pharmaceutical Industry:
(S)-TERT-BUTYL (1-(3-FLUOROPHENYL)-3-HYDROXYPROPAN-2-YL)CARBAMATE is used as a potential pharmaceutical compound for its possible interactions with biological targets such as enzymes, receptors, or proteins. Its structural features may allow it to modulate these targets, making it a candidate for further study in drug development.
Used in Drug Development Research:
In the field of drug development research, (S)-TERT-BUTYL (1-(3-FLUOROPHENYL)-3-HYDROXYPROPAN-2-YL)CARBAMATE serves as a valuable compound for exploring its potential effects on various biological processes. Its chiral nature and carbamate structure may provide insights into the design of novel therapeutic agents targeting specific diseases or conditions.
Used in Chemical Synthesis:
(S)-TERT-BUTYL (1-(3-FLUOROPHENYL)-3-HYDROXYPROPAN-2-YL)CARBAMATE may also be utilized as a synthetic building block or intermediate in the synthesis of more complex molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 114873-01-7 N-Boc-3-fluoro-L-phenylalanine 
• 848444-61-1 (S)-[1-(3-fluorobenzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 

Downstream Products

• 1026911-26-1 C₁₉H₂₂BrFN₂O₃ 
• 1131121-53-3 1,1-dimethylethyl {(1S)-2-[(5-bromo-6-chloro-1-oxido-3-pyridinyl)oxy]-1-[(3-fluorophenyl)methyl]ethyl}carbamate 
• 943325-38-0 2-[(2S)-2-amino-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione 
• 1047645-80-6 5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-N-{(1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-[(3-fluorophenyl)methyl]ethyl}-2-thiophenecarboxamide 
• 1047644-62-1 N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl] ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide 
• 1430058-15-3 C₃₅H₂₇FN₄O₃ 
• 1430058-14-2 C₃₀H₂₂FN₅O₃ 
• 1430057-35-4 2-[(1S)-2-amino-1-(3-fluorobenzyl)ethyl]-6-(4-chloro-1-methyl-1H-pyrazol-5-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one 
• 1430058-68-6 2-[(2S)-2-(6-chloro-3-oxo-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione 
• 1430056-70-4 5-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-[(1S)-1-(3-fluorobenzyl)-2-(methylamino)ethyl]isoindolin-1-one 
• 1430058-22-2 (2S)-2-[5-(4-chloro-1-methyl-1H-pyrazol-5-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]-3-(3-fluorophenyl)propanal 
• 1430058-19-7 5-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-[(1S)-1-(3-fluorobenzyl)-2-hydroxyethyl]isoindolin-1-one 
• 1430058-17-5 5-bromo-2-[(1S)-1-(3-fluorobenzyl)-2-hydroxyethyl]isoindolin-1-one 
• 1430056-55-5 2-[(1S)-2-amino-1-(3-fluorobenzyl)ethyl]-5-(4-phenyl-1-methyl-1H-pyrazol-5-yl)isoindolin-1-one 

Relevant articles and documents

AFURESERTIB: Protein kinase B (PKB) inhibitor Oncolytic

The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway plays key roles in cellular proliferation and survival. Mutations and alterations in this signal transduction pathway have been described in a variety of solid and hematopoietic malignancies, which may contribute to perpetuation of the disease in a number of ways. Increasing interest in targeting particular facets of this signaling cascade has led to the development of a number of novel anticancer agents, including afuresertib (GSK-2110183), an orally bioavailable pan-inhibitor of the RAC-alpha serine/threonine protein kinase, also referred to as protein kinase B or proto-oncogene c-Akt. The present review summarizes the preclinical and pharmacological aspects of afuresertib and early clinical experience.

INHIBITORS OF AKT ACTIVITY

Invented are novel pyrrole compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

INHIBITORS OF AKT ACTIVITY

Invented are novel hetero-pyrrole compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.