945001-78-5

Basic information

• Product Name: 5-amino-4-(3-hydroxy-4-methylphenyl)-2-cyclopropylamino-thieno[2,3-d]pyrimidine-6-carboxamide
• Synonyms: 5-amino-4-(3-hydroxy-4-methylphenyl)-2-cyclopropylamino-thieno[2,3-d]pyrimidine-6-carboxamide
• CAS NO: 945001-78-5
• Molecular Weight: 355.42
• Mol File: 945001-78-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-amino-4-(3-hydroxy-4-methylphenyl)-2-cyclopropylamino-thieno[2,3-d]pyrimidine-6-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-4-(3-hydroxy-4-methylphenyl)-2-cyclopropylamino-thieno[2,3-d]pyrimidine-6-carboxamide(945001-78-5)
• EPA Substance Registry System: 5-amino-4-(3-hydroxy-4-methylphenyl)-2-cyclopropylamino-thieno[2,3-d]pyrimidine-6-carboxamide(945001-78-5)

Safety Data

• Hazardous Substances Data: 945001-78-5(Hazardous Substances Data)

Upstream product

• 57295-30-4 3-hydroxy-4-methylbenzaldehyde 
• 765-30-0 Cyclopropylamine 

Relevant articles and documents

Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors

The serine/threonine specific protein kinase B-Raf is part of the MAPK pathway and is an interesting oncology target. We have identified thieno[2,3-d]pyrimidines as a core scaffold of small molecule B-Raf inhibitors. The SAR of analogs in this series will be described.