94562-26-2

Basic information

• Product Name: 1,3,7,8-Tetraazaspiro[4.5]deca-6,9-diene-10-carboxylic acid, 4-oxo-3-phenyl-2-thioxo-
• CAS NO: 94562-26-2
• Molecular Formula: C13H10N4O3S
• Molecular Weight: 302.313
• Mol File: 94562-26-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3,7,8-Tetraazaspiro[4.5]deca-6,9-diene-10-carboxylic acid, 4-oxo-3-phenyl-2-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,7,8-Tetraazaspiro[4.5]deca-6,9-diene-10-carboxylic acid, 4-oxo-3-phenyl-2-thioxo-(94562-26-2)
• EPA Substance Registry System: 1,3,7,8-Tetraazaspiro[4.5]deca-6,9-diene-10-carboxylic acid, 4-oxo-3-phenyl-2-thioxo-(94562-26-2)

Safety Data

• Hazardous Substances Data: 94562-26-2(Hazardous Substances Data)

Upstream product

• 59648-15-6 furo<3,4-d>pyridazine-5,7-dione 
• 103-85-5 monophenylthiourea 

Downstream Products

• 94562-29-5 2-Methylsulfanyl-4-oxo-3-phenyl-1,3,7,8-tetraaza-spiro[4.5]deca-1,6,9-triene-10-carboxylic acid methyl ester 

Relevant articles and documents

Pyridazine-4,5-dicarboxylic Anhydride: Versatile Synthon for the Preparation of 1,3,7,8-Tetra-azaspirodecane Derivatives with Nitrogen 1,3-Binucleophiles

The title compound (1) reacted smoothly with 1,2,3-triphenyl- and 1,3-diphenyl-guanidine, with N,N'-diphenyl- and N-phenyl-thiourea, and with benzamidine to give in very good yields the 1,3,7,8-tetra-azaspirodecane derivatives (2), (4), (6), (9), and (11), respectively, through a Smiles-type rearrangement.The reaction of compound (1) with 1,3-diphenylguanidine showed a different regiospecificity from that observed for the spiro-cyclization of dimethyl pyridazine-4,5-dicarboxylate (15) into methyl 4-oxo-1-phenyl-2-phenylimino-1,3,7,8-tetra-azaspirodeca-6,9-diene- 10-carboxylate (19), carried out with the same reagent in the presence of sodium hydride.The structures of the new heterospiro compounds were determined on the basis of chemical and specteroscopic evidence.