94569-19-4

Basic information

• Product Name: 2-aza-bicyclo[3.3.0]octane-3-carboxylic acid benzyl ester hydrochloride
• Synonyms: 2-aza-bicyclo[3.3.0]octane-3-carboxylic acid benzyl ester hydrochloride
• CAS NO: 94569-19-4
• Molecular Weight: 281.782
• Mol File: 94569-19-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-aza-bicyclo[3.3.0]octane-3-carboxylic acid benzyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aza-bicyclo[3.3.0]octane-3-carboxylic acid benzyl ester hydrochloride(94569-19-4)
• EPA Substance Registry System: 2-aza-bicyclo[3.3.0]octane-3-carboxylic acid benzyl ester hydrochloride(94569-19-4)

Safety Data

• Hazardous Substances Data: 94569-19-4(Hazardous Substances Data)

Upstream product

• 120-92-3 cyclopentanone 
• 59983-35-6 Cyclopentylidene-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 1296306-77-8 2-aza-bicyclo[3.3.0]octane-3-carboxylic acid 
• 100-51-6 benzyl alcohol 
• 765857-50-9 C₈H₁₁NO₂ 
• 93661-93-9 2,3,3a,4,5,6-Hexahydro-cyclopenta[b]pyrrole-2-carboxylic acid; hydrochloride 
• 87269-85-0 (±)-methyl 2-(acetylamino)-3-(2-oxocyclopentyl)-propionate 
• 7148-07-4 1-pyrrolidinocyclopent-1-ene 
• 87269-86-1 cis,endo-2-azabicyclo<3.3.0>octane-3-carboxylic acid hydrochloride 
• 87269-86-1 (1RS,3RS,5RS)-2-Azabicyclo<3.3.0>octan-3-carbonsaeure-hydrochlorid 
• 765857-50-9 (2S)-2,3,3a,4,5,6-hexahydrocyclopenta[b]pyrrole-2-carboxylic acid 
• 87269-86-1 (S,S,S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid hydrochloride 
• 109428-53-7 (2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid 
• 1296242-98-2 C₁₅H₁₇NO₂ 

Downstream Products

• 87269-87-2 benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride 
• 109428-53-7 (2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid 
• 87269-88-3 2--L-alanyl>-(1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester 
• 87269-86-1 (S,S,S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid hydrochloride 
• 2387-23-7 1,3-Dicyclohexylurea 
• 135214-79-8 S,S,S-2-azabicyclo[3,3,0]-octane-3-carboxylic acid benzyl ester L-mandelic acid salt 
• 1296242-98-2 C₁₅H₁₇NO₂ 
• 87333-19-5 Ramipril 

Relevant articles and documents

Shape Similarity by Fractal Dimensionality: An Application in the de novo Design of (?)-Englerin A Mimetics

Molecular shape and pharmacological function are interconnected. To capture shape, the fractal dimensionality concept was employed, providing a natural similarity measure for the virtual screening of de novo generated small molecules mimicking the structurally complex natural product (?)-englerin A. Two of the top-ranking designs were synthesized and tested for their ability to modulate transient receptor potential (TRP) cation channels which are cellular targets of (?)-englerin A. Intracellular calcium assays and electrophysiological whole-cell measurements of TRPC4 and TRPM8 channels revealed potent inhibitory effects of one of the computer-generated compounds. Four derivatives of this identified hit compound had comparable effects on TRPC4 and TRPM8. The results of this study corroborate the use of fractal dimensionality as an innovative shape-based molecular representation for molecular scaffold-hopping.

Asymmetric synthesis of (S,S,S)-2-Aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester: Formal synthesis of ramipril

An asymmetric synthesis of (S,S,S)-2-aza-bicyclo-[3.3.0]-octane-3- carboxylic acid benzyl ester 2 as an intermediate of angiotensin converting enzyme (ACE) inhibitor, ramipril 1, is described.

METHOD FOR THE PRODUCTION OF RAMIPRIL

An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method.