945996-91-8

Basic information

• Product Name: trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzeneboronic acid
• Synonyms: trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzeneboronic acid
• CAS NO: 945996-91-8
• Molecular Weight: 392.303
• Mol File: 945996-91-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzeneboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzeneboronic acid(945996-91-8)
• EPA Substance Registry System: trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-methoxy-benzeneboronic acid(945996-91-8)

Safety Data

• Hazardous Substances Data: 945996-91-8(Hazardous Substances Data)

Upstream product

• 2615-25-0 trans-1,4-cyclohexyldiamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 566172-78-9 n-butyl trans-(4-aminocyclohexyl)-carbamate 
• 15803-59-5 (1r,4r)-N¹-methylcyclohexane-1,4-diamine 
• 566172-79-0 trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane 
• 121124-97-8 3-formyl-4-methoxyphenylboronic acid 

Downstream Products

• 945999-95-1 trans-tert-butyl {4-[5-(6-amino-pyridin-3-yl)-2-methoxy-benzylamino]-cyclohexyl}-methyl-carbamate 
• 1025060-99-4 trans-tert-butyl {4-[(4'-cyano-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate 
• 945996-98-5 trans-3-{[[4-(Boc-methyl-amino)-cyclohexyl]-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-benzeneboronic acid 
• 945996-95-2 trans-3-{[[4-(Boc-methyl-amino)-cyclohexyl]-(3-chloro-4-fluoro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-benzeneboronic acid 
• 945996-93-0 trans-3-{[[4-(Boc-methyl-amino)-cyclohexyl]-(3-chlorobenzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-benzeneboronic acid 
• 1025061-58-8 C₃₅H₄₂ClN₅O₄S 
• 945997-14-8 trans-tert-butyl {4-[(3-chloro-benzo[b]thiophene-2-carbonyl)-(4'-cyano-4-methoxy-biphenyl-5-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate 
• 946000-02-8 trans-methyl 4-(3-{[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4-methylamino-cyclohexyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate 
• 1025061-31-7 trans-{4-[[5-(2-acetyl-pyridin-4-yl)-2-methoxy-benzyl]-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-cyclohexyl}-methyl-carbamic acid tert-butyl ester 
• 946000-01-7 trans-methyl 4-(3-{[[4-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl]-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate 
• 946000-20-0 trans-tert-butyl (4-{(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-[5-(2-dimethylcarbamoyl-pyridin-4-yl)-2-methoxy-benzyl]-amino}-cyclohexyl)-methyl-carbamate 
• 946000-09-5 trans-tert-butyl (4-{(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-[2-methoxy-5-(2-methylcarbamoyl-pyridin-4-yl)-benzyl]-amino}-cyclohexyl)-methyl-carbamate 
• 946000-03-9 trans-tert-butyl {4-[[5-(2-carbamoyl-pyridin-4-yl)-2-methoxy-benzyl]-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-cyclohexyl}-methyl-carbamate 
• 945997-16-0 trans-3-chloro-benzo[b]thiophene-2-carboxylic acid (4'-cyano-4-methoxy-biphenyl-3-ylmethyl)-(4-methylamino-cyclohexyl)-amide hydrochloride 

Relevant articles and documents

Potent agonists of the Hedgehog signaling pathway

A family of biaryl substituted 1,4-diaminocyclohexanamides of 3-chlorobenzothiophene-2-carboxylic acid is reported as picomolar modulators of Hedgehog protein function. SAR for the 1,4-diaminocyclohexane group is shown to be exquisitely sensitive to subst