946068-65-1

Basic information

• Product Name: (3S)-6,7-dimethoxy-3-((5R)-4-methoxy-6-methyl-9-phenyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one
• Synonyms: (3S)-6,7-dimethoxy-3-((5R)-4-methoxy-6-methyl-9-phenyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one
• CAS NO: 946068-65-1
• Molecular Weight: 489.525
• Mol File: 946068-65-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3S)-6,7-dimethoxy-3-((5R)-4-methoxy-6-methyl-9-phenyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-6,7-dimethoxy-3-((5R)-4-methoxy-6-methyl-9-phenyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one(946068-65-1)
• EPA Substance Registry System: (3S)-6,7-dimethoxy-3-((5R)-4-methoxy-6-methyl-9-phenyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one(946068-65-1)

Safety Data

• Hazardous Substances Data: 946068-65-1(Hazardous Substances Data)

Upstream product

• 488721-01-3 9-bromonoscapine 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

Synthesis and biological evaluation of novel biaryl type α-noscapine congeners

Natural α-noscapine, a known antitussive drug, is also now known to possess weak anticancer efficacy with relatively safe toxicity profile. In this study, we report synthesis and evaluation of novel biaryl type α-noscapine congeners designed by adding aryl unit to the tetrahydroisoquinoline part of natural α-noscapine core. Palladium catalyzed Suzuki cross coupling of 9-bromo α-noscapine with aryl boronic acids was employed using mild and inexpensive reagents to attain desired noscapinoids 5a-g in excellent yields. Screening anti-proliferative activity for new noscapinoids 5b-g, on human cancer cell lines resulted three compounds 5b, 5d and 5f as potent analogues, active against human breast epithelial (MCF-7), human cervix cancer (HeLa) and human lung adenocarcinoma epithelial (A549) cell lines.

2-(1-benzotriazolyl)pyridine: A robust bidentate ligand for the palladium-catalyzed C-C (Suzuki, Heck, Fujiwara-Moritani, Sonogashira), C-N and C-S coupling reactions

A new class of bidentate ligand, 1-(pyridine-2-yl)-1H-benzo[d][1,2,3] triazole has been designed and employed for the palladium-catalyzed C-C (Suzuki, Heck, Fujiwara-Moritani, and Sonogashira), C-N and C-S coupling reactions. The ligand was found to be inexpensive, thermally stable, easy to synthesize from easily accessible starting materials on a multigram scale, show simplicity in use, and robustness in application, making this ligand effective for different coupling reactions. Suitably, the donor ability of the N=N bond of the benzotriazole ring and lone pair of electrons on the N of the pyridine ring enhance the bidentate ability of the ligand.