946137-08-2

Basic information

• Product Name: 5-methoxy-1-(4-methoxybenzyl)-2-(trifluoromethyl)-1,2-dihydroquinoline
• Synonyms: 5-methoxy-1-(4-methoxybenzyl)-2-(trifluoromethyl)-1,2-dihydroquinoline
• CAS NO: 946137-08-2
• Molecular Weight: 349.353
• Mol File: 946137-08-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-methoxy-1-(4-methoxybenzyl)-2-(trifluoromethyl)-1,2-dihydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-1-(4-methoxybenzyl)-2-(trifluoromethyl)-1,2-dihydroquinoline(946137-08-2)
• EPA Substance Registry System: 5-methoxy-1-(4-methoxybenzyl)-2-(trifluoromethyl)-1,2-dihydroquinoline(946137-08-2)

Safety Data

• Hazardous Substances Data: 946137-08-2(Hazardous Substances Data)

Upstream product

• 6931-19-7 5-methoxyquinoline 
• 2746-25-0 p-Methoxybenzyl bromide 

Relevant articles and documents

Nucleophilic trifluoromethylation of azinium salts with Zn(CF3)2·bpy

(Trifluoromethyl)zinc complexes have been widely used in metal-mediated trifluoromethylation reactions. However, direct nucleophilic addition with a (trifluoromethyl)zinc complex is rare. In this article, we describe an unprecedented trifluoromethylation of azinium salts using Zn(CF3)2·bpy as CF3 source, giving 1-(4-methoxybenzyl)-2-(trifluoromethyl)-1,2-dihydroquinolines as products. The latter species were further transformed to 2-trifluoromethylquinolines under oxidative conditions. This work also shows that ligands play an important role in tuning the reactivity of (trifluoromethyl)zinc complexes.