946161-99-5

Basic information

• Product Name: 4-methyl-N-(4-methyl-2-phenylethynyl-phenyl)-benzenesulfonamide
• Synonyms: 4-methyl-N-(4-methyl-2-phenylethynyl-phenyl)-benzenesulfonamide
• CAS NO: 946161-99-5
• Molecular Weight: 361.464
• Mol File: 946161-99-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-(4-methyl-2-phenylethynyl-phenyl)-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(4-methyl-2-phenylethynyl-phenyl)-benzenesulfonamide(946161-99-5)
• EPA Substance Registry System: 4-methyl-N-(4-methyl-2-phenylethynyl-phenyl)-benzenesulfonamide(946161-99-5)

Safety Data

• Hazardous Substances Data: 946161-99-5(Hazardous Substances Data)

Upstream product

• 13141-44-1 4-methyl-2-(phenylethynyl)aniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 29289-13-2 2-iodo-4-methylaniline 
• 536-74-3 phenylacetylene 
• 2903-37-9 N-(2-chloro-4-methylphenyl)-4-methylbenzenesulfonamide 
• 852292-23-0 N-(2-iodo-4-methylphenyl)-4-methylbenzenesulfonamide 

Downstream Products

• 1388136-42-2 5-methyl-4-methoxy-2-phenyl-1-tosyl-1H-indole 

Relevant articles and documents

Stereoselective synthesis of 2,3-disubstituted indoline, pyrrolidine and cyclic ether-fused 1,2-dihydroquinoline derivatives using alkyne iminium ion cyclization of vinylogous carbamates: Switch of regioselectivity using an internal hydroxy group as a nucleophile

An intramolecular, alkyne iminium ion cyclization of vinylogous carbamates derived from o-alkynyl anilines and N-protected homopropargyl amines is developed for the stereoselective construction of trans-2,3-disubstituted indolines and pyrrolidine derivatives, respectively. The regioselectivity of the alkyne iminium ion cyclization could be switched using a hydroxy group as an internal nucleophile resulting in cyclic ether-fused 1,2-dihydroquinolines. The entire process of nitrogen heterocycle formation can also be carried out in a 'one-pot' manner starting from o-iodo aniline derivatives.

Synthesis of15N-labeled heterocyclesviathe cleavage of C-N bonds of anilines and glycine-15N

A nitrogen replacement process that directly incorporates the15N atom of glycine-15N into anilines was reported. The process involves a Csp2-N bond cleavage of anilines driven by dearomatization and a Csp3-N bond cleavage of glycine-15N driven by aromatization. A variety of15N-labeled aromatic heterocycles can be preparedviathis process.

Nickel-Catalyzed Arylative Additions on 2-Alkynyl-N-Arylsulfonylanilides to Construct Functionalized Indoles

The addition of aryl iodides to 2-alkynyl-N-sulfonylanilides to form 2,3-difunctionalized N-arylsulfonylindoles can be catalyzed using a nickel catalyst ligated to a bis(cyclohexanyl)phosphinoferrocene. A variety of nickel complexes can be used as precata