946197-48-4

Basic information

• Product Name: 1-N-allyl-2,6-dibromo-4-fluoroaniline
• Synonyms: 1-N-allyl-2,6-dibromo-4-fluoroaniline
• CAS NO: 946197-48-4
• Molecular Weight: 308.976
• Mol File: 946197-48-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-N-allyl-2,6-dibromo-4-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-allyl-2,6-dibromo-4-fluoroaniline(946197-48-4)
• EPA Substance Registry System: 1-N-allyl-2,6-dibromo-4-fluoroaniline(946197-48-4)

Safety Data

• Hazardous Substances Data: 946197-48-4(Hazardous Substances Data)

Upstream product

• 344-18-3 2,6-dibromo-4-fluoroaniline 
• 106-95-6 allyl bromide 

Downstream Products

• 883001-24-9 7-bromo-5-fluoro-3-methyl-1H-indole 
• 882999-50-0 (2E)-3-(5-fluoro-3-methyl-1H-indol-7-yl)acrylic acid 
• 861238-35-9 [2H]-DG-041 
• 883000-78-0 7-bromo-1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indole 
• 957125-56-3 N-allyl-N-(2,4-dichlorobenzyl)-2,6-dibromo-4-fluoroaniline 

Relevant articles and documents

Development of a scalable process for DG-041, a potent EP3 receptor antagonist, via tandem heck reactions

DG-041 is a small molecule antagonist of the EP3 receptor for prostaglandin E2 that is in clinical development for treatment of peripheral artery disease (PAD). Originally produced using a six-step synthetic procedure, process optimization led to development of a four-step sequence that is readily scalable. The key step in the optimized sequence contains two sequential Heck reactions, involving an intramolecular Heck cyclization followed by an intermolecular Heck coupling, performed in one pot to produce a highly substituted indole core.

7-(ACRYLOYL) INDOLE COMPOSITIONS AND METHODS FOR MAKING AND USING SAME

The present invention is directed to pharmaceutical compositions of 7-(acryloyl) indoles, such as 4,5-Dichloro-thiophene-2-sulfonic acid [(E)-3-[1-(2,4-dichlorophenylmethyl)-5-fluoro-3-methyl-1H-indol-7-yl]-acryloyl]amide (DTSI). The invention is also dir