94622-89-6

Basic information

• Product Name: 5-bromo-2-methoxy-α,α-diphenylbenzenemethanol
• Synonyms: 5-bromo-2-methoxy-α,α-diphenylbenzenemethanol
• CAS NO: 94622-89-6
• Molecular Weight: 369.258
• Mol File: 94622-89-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-bromo-2-methoxy-α,α-diphenylbenzenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-methoxy-α,α-diphenylbenzenemethanol(94622-89-6)
• EPA Substance Registry System: 5-bromo-2-methoxy-α,α-diphenylbenzenemethanol(94622-89-6)

Safety Data

• Hazardous Substances Data: 94622-89-6(Hazardous Substances Data)

Upstream product

• 64655-62-5 (2-methoxyphenyl)(diphenyl)methanol 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 119-61-9 benzophenone 
• 100-66-3 methoxybenzene 
• 591-51-5 phenyllithium 
• 60-29-7 diethyl ether 

Downstream Products

• 72824-75-0 ((2-methoxyphenyl)methylene)dibenzene 
• 103389-56-6 bis-[(5-bromo-2-methoxy-phenyl)-diphenyl-methyl]-peroxide 
• 102024-94-2 4-bromo-2-(α-chloro-benzhydryl)-anisole 
• 857591-20-9 2-benzhydryl-4-bromo-anisole 

Relevant articles and documents

Focused ortho-Lithiation and Functionalization of p-Bromo- and p-Iodoanisole

By use of the strategy for ortho-lithiation (DoM) that conceptually diminishes the pKA difference between the ortho-H of the substrate and the conjugate acid of the metalating agent, effective metalation of bromine and iodine bearing aryl substrates can be carried out. As a set of prototypes, p-bromoanisole (p-BrA) and p-iodoanisole (p-IA) have been successfully ortho-metalated in promoted hydrocarbon media using ortho-lithiodimethylbenzylamine (o-LiDMBA) as the metalating agent. No hint of exchange of either halogen was noted using these conditions. These studies add to the emerging evidence of a hitherto unidentified acidifying effect on the proton(s) ortho- to a directing metalation group (DMG) by both a p-iodo and a p-bromo substituent.