946438-16-0Relevant articles and documents
Nickel-Catalyzed Reduction of Secondary and Tertiary Amides
Simmons, Bryan J.,Hoffmann, Marie,Hwang, Jaeyeon,Jackl, Moritz K.,Garg, Neil K.
, p. 1910 - 1913 (2017)
The nickel-catalyzed reduction of secondary and tertiary amides to give amine products is reported. The transformation is tolerant of extensive variation with respect to the amide substrate, proceeds in the presence of esters and epimerizable stereocenters, and can be used to achieve the reduction of lactams. Moreover, this methodology provides a simple tactic for accessing medicinally relevant α-deuterated amines.
One-pot amidation of olefins through Pd-catalyzed coupling of alkylboranes and carbamoyl chlorides
Yasui, Yoshizumi,Tsuchida, Sayo,Miyabe, Hideto,Takemoto, Yoshiji
, p. 5898 - 5900 (2008/02/09)
(Chemical Equation Presented) A one-pot synthesis of C1- elongated amides starting from olefins and carbamoyl chlorides has been developed. Alkyl-boranes, generated by hydroboration of terminal olefins with 9-BBN-H, underwent smooth coupling with carbamoyl chlorides in the presence of palladium catalyst and Cs2CO3.