94649-70-4

Basic information

• Product Name: 1-(2-chloro-4-hydroxy-3,5-dimethoxyphenyl)ethanone
• Synonyms: 1-(2-Chloro-4-hydroxy-3,5-dimethoxyphenyl)ethanone;Ethanone, 1-(2-chloro-4-hydroxy-3,5-dimethoxyphenyl)-
• CAS NO: 94649-70-4
• Molecular Formula: C₁₀H₁₁ClO₄
• Molecular Weight: 230.6449
• Mol File: 94649-70-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 93–94°C
• Boiling Point: 335.4°C at 760 mmHg
• Flash Point: 156.7°C
• Density: 1.285g/cm³
• Vapor Pressure: 6.16E-05mmHg at 25°C
• Refractive Index: 1.541
• PKA: 7.24±0.28(Predicted)
• CAS DataBase Reference: 1-(2-chloro-4-hydroxy-3,5-dimethoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloro-4-hydroxy-3,5-dimethoxyphenyl)ethanone(94649-70-4)
• EPA Substance Registry System: 1-(2-chloro-4-hydroxy-3,5-dimethoxyphenyl)ethanone(94649-70-4)

Safety Data

• Hazardous Substances Data: 94649-70-4(Hazardous Substances Data)

Usage

Preparation

Preparation by chlorination of acetosyringone (4-hydroxy-3,5-dimethoxyacetophenone) in dioxane with 1.0–1.1 mol. equiv. chlorine in acetic acid.

Upstream product

• 2478-38-8 1-(4-hydroxy-3,5-dimethoxy-phenyl)-ethanone 

Relevant articles and documents

Preparation and properties of chlorinated syringic acids, acetosyringones, acetoguaiacones and methoxy-p-hydroquinones components of pulp bleaching effluents

A range of chlorinated phenols which serve as standards for compounds occurring in effluents from the bleaching of wood pulps with chlorine-containing reagents has been prepared. The chlorinated phenols include chlorosyringic acids, chloroacetosyringones, chloroacetoguaiacones, 5-chloro-2-methoxy-p-hydroquinone and chloro-2,6-dimethoxy-p-hydroquinones. With the exception of the ring-chlorinated acetoguaiacones which were prepared by reaction of chlorovanillin acetates with diazomethane, the compounds were obtained by direct chlorination of appropriate phenols or their acetates. Gas chromatographic and mass spectrometric data for the acetylated phenols are given.