94675-54-4Relevant articles and documents
Microwave assisted combinatorial chemistry. Synthesis of substituted pyridines
Cotterill, Ian C.,Usyatinsky, Alexander Ya.,Arnold, John M.,Clark, Douglas S.,Dordick, Jonathan S.,Michels, Peter C.,Khmelnitsky, Yuri L.
, p. 1117 - 1120 (2007/10/03)
A new highly efficient MICROCOS technology (Microwave-assisted Combinatorial Synthesis) for generating combinatorial libraries is described. The technology is applied to the high throughput, automated, one-step, parallel synthesis of diverse substituted pyridines using the Hantzsch synthesis. The advantages of microwave-assisted chemistry for combinatorial synthesis include a broad range of available chemistries, simple reaction setup and product recovery readily amenable to automation, extremely short reaction times, and high product yields.