947153-64-2

Basic information

• Product Name: PALMATINE CHLORIDE
• Synonyms: Berbinium,7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxy-, chloride (8CI); Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3,9,10-tetramethoxy-, chloride (9CI); Palmatine chloride(6CI,7CI); Fibrauretin
• CAS NO: 947153-64-2
• Molecular Formula: C21H22 N O4 . Cl
• Molecular Weight: 0
• Mol File: 947153-64-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PALMATINE CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PALMATINE CHLORIDE(947153-64-2)
• EPA Substance Registry System: PALMATINE CHLORIDE(947153-64-2)

Safety Data

• Hazardous Substances Data: 947153-64-2(Hazardous Substances Data)

Upstream product

• 64705-37-9 2-(2-iodo-4,5-dimethoxyphenyl)ethanol 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 4393-09-3 2,3-dimethoxybenzyl amine 
• 80-48-8 methyl p-toluene sulfonate 
• 633-65-8 berberine chloride 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 616-38-6 carbonic acid dimethyl ester 
• 1239085-76-7 2-(2-ethynyl-4,5-dimethoxyphenyl)ethanol 
• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 

Downstream Products

• 26067-60-7 2,3,9,10-tetramethoxy-5,8-dihydro-6H-isoquinolino[3,2-α]isoquinoline 
• 63490-92-6 polycarpine 

Relevant articles and documents

Cobalt-Mediated Decarboxylative/Desilylative C?H Activation/Annulation Reaction: An Efficient Approach to Natural Alkaloids and New Structural Analogues

A Co(II)-mediated decarboxylative/desilylative C?H activation/annulation reaction for the efficient synthesis of 3-arylisoquinolines has been developed. Using alkynyl carboxylic acid and alkynyl silane as terminal alkyne precursors, providing straightforw

Highly efficient synthesis and monoamine oxidase B inhibitory profile of demethyleneberberine, columbamine and palmatine

The biosynthesis of berberine alkaloids is thought to begin with the demethylation of berberine followed by methylation reactions to generate other type berberine alkaloids. This seemingly expeditious way to access berberine alkaloids has been stagnated for over half a century due to certain vexing synthetic problems, such as low isolated yield, complex operations and toxic reagents. We further investigated this bioinspired semi-synthesis strategy and significantly improved the synthetic efficacy, by providing a practical synthetic process for demethyleneberberine (DMB), columbamine and palmatine. Furthermore, we found that DMB (IC50, 9.06 μM) inhibited the activity of monoamine oxidase B (MAO-B), an enzyme that deaminates dopamine and is particularly involved in the pathology of Parkinson's disease. Besides, columbamine was able to decrease MAO-B activity by approximately 40%. These findings provide perquisites for further in vivo investigation to confirm the therapeutic potentiality of berberine alkaloids, DMB in particular.

Water-mediated C-H activation of arenes with secure carbene precursors: The reaction and its application

A water-mediated C-H activation using sulfoxonium ylides is reported, providing a general, green and step-economic approach to construct a C-C bond and varieties of useful N-heterocycle scaffolds. Notably, the "water-mediated" activation, in contrast to that in organic solvents, shows great potential in pharmaceutical, biochemistry and chemical industries.