947523-45-7

Basic information

• Product Name: 3-methoxy-4-nitrobenzaldehyde oxime
• Synonyms: 3-methoxy-4-nitrobenzaldehyde oxime
• CAS NO: 947523-45-7
• Molecular Weight: 196.163
• Mol File: 947523-45-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-methoxy-4-nitrobenzaldehyde oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxy-4-nitrobenzaldehyde oxime(947523-45-7)
• EPA Substance Registry System: 3-methoxy-4-nitrobenzaldehyde oxime(947523-45-7)

Safety Data

• Hazardous Substances Data: 947523-45-7(Hazardous Substances Data)

Upstream product

• 80410-57-7 3-methoxy-4-nitrobenzaldehyde 
• 704-13-2 5-formyl-2-nitrophenol 

Downstream Products

• 1433663-58-1 3-(3-methoxy-4-nitrophenyl)-5,6-dihydrobenzo[d]isoxazol-7(4H)-one 
• 1433663-62-7 3-(4-amino-3-methoxyphenyl)-5,6-dihydrobenzo[d]isoxazol-7(4H)-one 
• 1433663-66-1 N-(2-methoxy-4-(7-oxo-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-yl)phenyl)formamide 
• 1433663-73-0 N-(2-methoxy-4-(7-oxo-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-yl)phenyl)-N-(2-oxopropyl)formamide 
• 1433663-77-4 3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-5,6-dihydrobenzo[d]isoxazol-7(4H)-one 
• 1433663-81-0 3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol 
• 1433663-13-8 7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol 
• 1433663-23-0 7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole 
• 1433663-28-5 7-(4-fluorophenoxy)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole 
• 1433663-38-7 7-(3,5-difluorobenzyloxy)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazole 
• 1433663-33-2 7-(3,5-difluorophenoxy)-4,5,6,7-tetrahydro-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1,2-benzisoxazole 
• 1433663-18-3 C₂₅H₂₃F₂N₃O₃ 
• 1433662-85-1 C₂₄H₃₀N₄O₂ 
• 1433662-91-9 C₂₀H₂₁F₃N₄O₂ 

Relevant articles and documents

Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators

The design and synthesis of a new series of tetrahydrobenzisoxazoles as modulators of γ-secretase activity and their structure-activity relationship (SAR) will be detailed. Several compounds are active γ-secretase modulators (GSMs) with good to excellent selectivity for the reduction of Aβ42 in the cellular assay. Compound 14a was tested in vivo in a nontransgenic rat model and was found to significantly reduce Aβ42 in the CNS compartment compared to vehicle-treated animals (up to 58% reduction of cerebrospinal fluid Aβ42 as measured 3 h after an acute oral dosing at 30 mg/kg).