947538-47-8

Basic information

• Product Name: C₄₈H₅₄N₈O₅S
• Synonyms: C₄₈H₅₄N₈O₅S
• CAS NO: 947538-47-8
• Molecular Weight: 855.073
• Mol File: 947538-47-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₈H₅₄N₈O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₈H₅₄N₈O₅S(947538-47-8)
• EPA Substance Registry System: C₄₈H₅₄N₈O₅S(947538-47-8)

Safety Data

• Hazardous Substances Data: 947538-47-8(Hazardous Substances Data)

Upstream product

• 142356-33-0 tert-butyl 6-bromohexylcarbamate 
• 29823-18-5 ethyl 7-bromoheptanoate 
• 30515-28-7 7-bromoheptanoic acid 
• 947538-46-7 C₄₉H₅₄N₂O₅S 
• 924273-15-4 6-(S-tritylsulfanyl)-hexaneamine 
• 947538-45-6 C₃₀H₃₇NO₂S 
• 952582-40-0 C₃₄H₄₄N₂O₃S 
• 197151-79-4 pteroyl azide 
• 794587-35-2 6-bromohexyl isocyanate 

Relevant articles and documents

Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors

Aiming to develop selective anticancer drugs, we designed and synthesized three disulfides bearing a folic acid moiety as candidate folate receptor (FR)-targeted prodrugs of thiolate histone deacetylase inhibitors. Among them, compound 1 displayed growth-inhibitory activity toward folate receptor-positive MCF-7 breast cancer cells. The activity of 1 was significantly reduced by free folic acid, suggesting that cellular uptake of 1 is mediated by FR.