947589-83-5

Basic information

• Product Name: 4-{1-[4-(trifluoromethyl)benzyl]-5-methoxy-1H-indol-3-yl}-2-hydroxy-4-oxobut-2-enoic acid
• Synonyms: 4-{1-[4-(trifluoromethyl)benzyl]-5-methoxy-1H-indol-3-yl}-2-hydroxy-4-oxobut-2-enoic acid
• CAS NO: 947589-83-5
• Molecular Weight: 419.357
• Mol File: 947589-83-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{1-[4-(trifluoromethyl)benzyl]-5-methoxy-1H-indol-3-yl}-2-hydroxy-4-oxobut-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{1-[4-(trifluoromethyl)benzyl]-5-methoxy-1H-indol-3-yl}-2-hydroxy-4-oxobut-2-enoic acid(947589-83-5)
• EPA Substance Registry System: 4-{1-[4-(trifluoromethyl)benzyl]-5-methoxy-1H-indol-3-yl}-2-hydroxy-4-oxobut-2-enoic acid(947589-83-5)

Safety Data

• Hazardous Substances Data: 947589-83-5(Hazardous Substances Data)

Upstream product

• 947589-69-7 ethyl 4-{1-[4-(trifluoromethyl)benzyl]-5-methoxy-1H-indol-3-yl}-2-hydroxy-4-oxobut-2-enoate 
• 947589-65-3 3-acetyl-5-methoxy-1-(4-(trifluoromethyl)benzyl)-1H-indole 
• 51843-22-2 3-acetyl-5-methoxyindole 
• 1006-94-6 5-methoxylindole 

Relevant articles and documents

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition

Therapeutic treatment of AIDS is recently characterized by a crescent effort towards the identification of multiple ligands able to target different steps of HIV-1 life cycle. Taking into consideration our previously obtained SAR information and combining some important chemical structural features we report herein the synthesis of novel benzyl-indole derivatives as anti-HIV agents. Through this work we identified new dual target small molecules able to inhibit both IN-LEDGF/p75 interaction and the IN strand-transfer step considered as two crucial phases of viral life cycle.