947674-87-5

Basic information

• Product Name: N-[(1R)-2,3-Dihydro-6-hydroxy-1H-inden-1-yl]carbamic acid tert-butyl ester
• Synonyms: N-[(1R)-2,3-Dihydro-6-hydroxy-1H-inden-1-yl]carbamic acid tert-butyl ester;(R)-6-hydroxy-N-Boc-1-aminoindane
• CAS NO: 947674-87-5
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Mol File: 947674-87-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 406.2 °C at 760 mmHg
• Flash Point: 199.4 °C
• Appearance: /
• Density: 1.18
• Refractive Index: 1.564
• CAS DataBase Reference: N-[(1R)-2,3-Dihydro-6-hydroxy-1H-inden-1-yl]carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1R)-2,3-Dihydro-6-hydroxy-1H-inden-1-yl]carbamic acid tert-butyl ester(947674-87-5)
• EPA Substance Registry System: N-[(1R)-2,3-Dihydro-6-hydroxy-1H-inden-1-yl]carbamic acid tert-butyl ester(947674-87-5)

Safety Data

• Hazardous Substances Data: 947674-87-5(Hazardous Substances Data)

Usage

Description

N-[(1R)-2,3-Dihydro-6-hydroxy-1H-inden-1-yl]carbamic acid tert-butyl ester is a carbamic acid ester with the molecular formula C14H21NO4. It features a 1R configuration and a 2,3-dihydro-6-hydroxy-1H-inden-1-yl group, which endows it with unique biological and pharmacological properties. This chemical compound has potential applications in the pharmaceutical industry, particularly in the development of new drugs targeting specific biological pathways.

Uses

Used in Pharmaceutical Industry:
N-[(1R)-2,3-Dihydro-6-hydroxy-1H-inden-1-yl]carbamic acid tert-butyl ester is used as a chemical intermediate for the development of new drugs. Its unique structure and properties make it a promising candidate for targeting specific biological pathways, which can lead to the creation of innovative therapeutic agents.
Used in Drug Development:
In the field of drug development, N-[(1R)-2,3-Dihydro-6-hydroxy-1H-inden-1-yl]carbamic acid tert-butyl ester is utilized as a key component in the synthesis of potential pharmaceuticals. Its presence in these compounds can contribute to their efficacy and selectivity, making it a valuable asset in the advancement of medicine and pharmacology.

InChI:InChI=1/C14H19NO3/c1-14(2,3)18-13(17)15-12-7-5-9-4-6-10(16)8-11(9)12/h4,6,8,12,16H,5,7H2,1-3H3,(H,15,17)/t12-/m1/s1

Upstream product

• 209394-88-7 6-chloroacetoxy-N-trifluoroacetyl-(R)-1-aminoindan 
• 209394-87-6 6-chloroacetyl-N-trifluoroacetyl-(R)-1-aminoindan 
• 155666-94-7 N-trifluoroacetyl-(R)-1-aminoindan 
• 10277-74-4 (R)-1-Aminoindane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 169105-01-5 (R)-3-amino-2,3-dihydro-1H-inden-5-ol 

Downstream Products

• 209394-27-4 ladostigil 

Relevant articles and documents

Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors

We report the discovery of a novel series of ATP-competitive Janus kinase 3 (JAK3) inhibitors based on the 5H-pyrrolo[2,3-b]pyrazine scaffold. The initial leads in this series, compounds 1a and 1h, showed promising potencies, but a lack of selectivity against other isoforms in the JAK family. Computational and crystallographic analysis suggested that the phenyl ether moiety possessed a favorable vector to achieve selectivity. Exploration of this vector resulted in the identification of 12b and 12d, as potent JAK3 inhibitors, demonstrating improved JAK family and kinase selectivity.