94796-13-1

Basic information

• Product Name: diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate
• Synonyms: diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate
• CAS NO: 94796-13-1
• Molecular Weight: 510.613
• Mol File: 94796-13-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate(94796-13-1)
• EPA Substance Registry System: diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate(94796-13-1)

Safety Data

• Hazardous Substances Data: 94796-13-1(Hazardous Substances Data)

Upstream product

• 5350-57-2 benzophenone hydrazone 
• 908093-98-1 diazodiphenylmethane 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 122553-60-0 (6R,7R)-8-Oxo-7-phenylacetylamino-3-trifluoromethanesulfonyloxy-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 122553-60-0 (6R,7R)-benzhydryl 8-oxo-7-(2-phenylacetamido)-3-(((trifluoromethyl)sulfonyl)oxy)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 54639-48-4 (6R,7R)-benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 64276-70-6 (6R,7R)-3-Bromomethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 103-80-0 phenylacetyl chloride 
• 28240-15-5 3-hydroxymethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 15690-38-7 (6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 103-82-2 phenylacetic acid 
• 35246-64-1 (6R,7R)-benzhydryl 3-(hydroxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 50-00-0 formaldehyd 
• 593-60-2 Vinyl bromide 

Downstream Products

• 33748-00-4 7-(phenylacetamido)-3-vinylcephem-4-carboxylic acid 
• 131309-06-3 Benzhydryl 7-Phenylacetamido-3-(3'-pyrazolyl)-3-cephem-4-carboxylate 1S-(β)-Oxide 
• 123201-39-8 diphenylmethyl 7β-[2-(2-tritylaminothiazol-4-yl)-(Z)-2-tritylhydroxyimino]-3-vinyl-3-cephem-4-carboxylate 
• 128454-32-0 7β-[(Z)-2-(2-amino-4-thiazolyl)-2-(trityloxyamino)acetamido]-3-vinylcephem-4-carboxylic acid 
• 91832-40-5 cefdinir 
• 124667-18-1 Benzhydryl 7-Phenylacetamido-3-(2',2'-diphenylcyclopropyl)-3-cephem-4-carboxylate 
• 124667-19-2 Benzhydryl 7-Phenylacetamido-3-(2',2'-diphenylcyclopropyl)-3-cephem-4-carboxylate 
• 131309-05-2 Benzhydryl 7-Phenylacetamido-3-vinyl-3-cephem-4-carboxylate 1S-(β)-Oxide 
• 131330-63-7 4a-(4,5-Dihydro-3H-pyrazol-3-yl)-1-oxo-2-phenylacetylamino-2,2a,4a,5-tetrahydro-1H,4H-3-thia-6,7,7b-triaza-cyclobuta[e]indene-7a-carboxylic acid benzhydryl ester 
• 124667-16-9 Diphenylmethyl (6R,7R)-7-phenylacetamido-3-(1-pyrazolin-3-yl)ceph-3-em-4-carboxylate 
• 131330-63-7 Benzhydryl 7-Phenylacetamido-3-(3'-pyrazolyl)-3,4-(4'',3''-pyrazolino)cepham-4-carboxylate 

Relevant articles and documents

A method for synthesizing spore parent nucleus antibiotiki head

The invention belongs to the technical field of synthesis of cephalosporin intermediates and in particular relates to a synthesis method of antibiotic cephalosporin mother nucleus. The synthesis method of the antibiotic cephalosporin mother nucleus comprises the following steps: (1) preparing a reaction liquid I; (2) preparing a reaction liquid II; (3) preparing a compound GVNA; and (4) preparing AVNA. The synthesis method of the antibiotic cephalosporin mother nucleus has the advantages that production cost is low, reaction time is short, recovery rate of the organic solvent is high, secondary utilization is facilitated, and product yield is high.

Reductive cross-coupling of 3-substituted Δ3-cephems with alkenyl halides in an Al/PbBr2/NiBr2(bpy) triplemetal redox system. Synthesis of 3-alkenyl-Δ3-cephems

Synthesis of 3-alkenyl-Δ3-cephems was performed successfully by cross-coupling 3-(trifluoromethylsulfonyloxy or chloro)-Δ3-cephem with alkenyl halides, e.g., vihyl bromide, trans-1-bromo-1-propene, and trans-β-bromostyrene in an Al/cat·PbBr2/cat·NiBr2(bpy)/NMP (or DMF) system. Reduction of 3-(trifluoromethylsulfonyloxy)-Δ3-cephem into norcephalosporin was also achieved by a similar reaction in the presence of 5 molar equiv of water. Scope and a plausible mechanism of the Al/Pb/Ni triplemetal-redox promoted reactions are discussed.

N,N'-diisopropyl-O-diphenylmethyl isourea: A mild and convenient alklating agent for the formation of cephalosporin derivatives derivatives

N,N'-Diisopropyl-O-diphenylmethyl isourea reacts with cephalosporin-4- carboxylic acid in tetrahydrofuran at room temperature to give the diphenylmethyl (DPM) ester in good yields without isomerization of the double bond from C-3 to C-2.