948021-68-9

Basic information

• Product Name: C₂₀H₁₉ClN₄O₄
• Synonyms: C₂₀H₁₉ClN₄O₄
• CAS NO: 948021-68-9
• Molecular Weight: 414.848
• Mol File: 948021-68-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₉ClN₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₉ClN₄O₄(948021-68-9)
• EPA Substance Registry System: C₂₀H₁₉ClN₄O₄(948021-68-9)

Safety Data

• Hazardous Substances Data: 948021-68-9(Hazardous Substances Data)

Upstream product

• 22876-17-1 6-amino-1,3-benzoxazol-2-(3H)-one 
• 337530-42-4 (3S)-1-(4-chlorophenyl)-3-methylpiperazine 

Relevant articles and documents

Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimization

Selective N-methyl-D-aspartate receptor subunit 2B (NR2B) antagonists show potential as analgesic drugs, and do not cause side effects associated with non-selective N-methyl-D-aspartate (NMDA) antagonists. Using a scaffold-hopping approach, we previously identified isoxazole derivative 4 as a potent selective NR2B antagonist. In this study, further scaffold hopping of isoxazole derivative 4 and optimization of its pharmacokinetic profile led to the discovery of the orally bioavailable compound 6v. In a rat study of analgesia, 6v demonstrated analgesic effects against neuropathic pain.